Polymerbundne camptothecinderivater

PCT No. PCT/EP94/03154 Sec. 371 Date Jun. 8, 1995 Sec. 102(e) Date Jun. 8, 1995 PCT Filed Sep. 21, 1994 PCT Pub. No. WO95/10304 PCT Pub. Date Apr. 20, 1995A polymeric conjugate consists essentially of: (i) from 60 to 99 mol % of N-(2-hydroxypropyl) methacryloylamide units represented by formula 1: e...

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Hauptverfasser:	SUARATO, ANTONINO, ANGELUCCI, FRANCESCO
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Sprache:	dan
Schlagworte:	CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP
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creator	SUARATO, ANTONINO ANGELUCCI, FRANCESCO
description	PCT No. PCT/EP94/03154 Sec. 371 Date Jun. 8, 1995 Sec. 102(e) Date Jun. 8, 1995 PCT Filed Sep. 21, 1994 PCT Pub. No. WO95/10304 PCT Pub. Date Apr. 20, 1995A polymeric conjugate consists essentially of: (i) from 60 to 99 mol % of N-(2-hydroxypropyl) methacryloylamide units represented by formula 1: ethacryloylglycyl-aminoacyl) camptothecin units represented by formula 2 2 wherein [A] is a spacer group having respective terminal amino and carbonyl groups which are separated by at least three atoms and O-CPT represents a residue of a camptothecin, the C-20 hydroxy group of the camptothecin being linked to the terminal carbonyl group of the spacer group [A]; and (iii) from 0 to 10 mol % of N-methacryloylglycine or N-(2-hydroxy-propyl)methacryloylglycinamide units represented by formula 3: 3 wherein Z represents hydroxy or a residue of formula -NH-CH2-CH(OH)-CH3.
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Date Apr. 20, 1995A polymeric conjugate consists essentially of: (i) from 60 to 99 mol % of N-(2-hydroxypropyl) methacryloylamide units represented by formula 1: ethacryloylglycyl-aminoacyl) camptothecin units represented by formula 2 2 wherein [A] is a spacer group having respective terminal amino and carbonyl groups which are separated by at least three atoms and O-CPT represents a residue of a camptothecin, the C-20 hydroxy group of the camptothecin being linked to the terminal carbonyl group of the spacer group [A]; and (iii) from 0 to 10 mol % of N-methacryloylglycine or N-(2-hydroxy-propyl)methacryloylglycinamide units represented by formula 3: 3 wherein Z represents hydroxy or a residue of formula -NH-CH2-CH(OH)-CH3.</description><edition>6</edition><language>dan</language><subject>CHEMISTRY ; COMPOSITIONS BASED THEREON ; HUMAN NECESSITIES ; HYGIENE ; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC MACROMOLECULAR COMPOUNDS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030825&DB=EPODOC&CC=DK&NR=0673258T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030825&DB=EPODOC&CC=DK&NR=0673258T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SUARATO, ANTONINO</creatorcontrib><creatorcontrib>ANGELUCCI, FRANCESCO</creatorcontrib><title>Polymerbundne camptothecinderivater</title><description>PCT No. PCT/EP94/03154 Sec. 371 Date Jun. 8, 1995 Sec. 102(e) Date Jun. 8, 1995 PCT Filed Sep. 21, 1994 PCT Pub. 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Date Apr. 20, 1995A polymeric conjugate consists essentially of: (i) from 60 to 99 mol % of N-(2-hydroxypropyl) methacryloylamide units represented by formula 1: ethacryloylglycyl-aminoacyl) camptothecin units represented by formula 2 2 wherein [A] is a spacer group having respective terminal amino and carbonyl groups which are separated by at least three atoms and O-CPT represents a residue of a camptothecin, the C-20 hydroxy group of the camptothecin being linked to the terminal carbonyl group of the spacer group [A]; and (iii) from 0 to 10 mol % of N-methacryloylglycine or N-(2-hydroxy-propyl)methacryloylglycinamide units represented by formula 3: 3 wherein Z represents hydroxy or a residue of formula -NH-CH2-CH(OH)-CH3.</description><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2003</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAOyM-pzE0tSirNS8lLVUhOzC0oyS_JSE3OzEtJLcosSyxJLeJhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfEu3gZm5sZGphYhIcbGxKgBAEq3J8E</recordid><startdate>20030825</startdate><enddate>20030825</enddate><creator>SUARATO, ANTONINO</creator><creator>ANGELUCCI, FRANCESCO</creator><scope>EVB</scope></search><sort><creationdate>20030825</creationdate><title>Polymerbundne camptothecinderivater</title><author>SUARATO, ANTONINO ; ANGELUCCI, FRANCESCO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_DK0673258TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>dan</language><creationdate>2003</creationdate><topic>CHEMISTRY</topic><topic>COMPOSITIONS BASED THEREON</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC MACROMOLECULAR COMPOUNDS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>THEIR PREPARATION OR CHEMICAL WORKING-UP</topic><toplevel>online_resources</toplevel><creatorcontrib>SUARATO, ANTONINO</creatorcontrib><creatorcontrib>ANGELUCCI, FRANCESCO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SUARATO, ANTONINO</au><au>ANGELUCCI, FRANCESCO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Polymerbundne camptothecinderivater</title><date>2003-08-25</date><risdate>2003</risdate><abstract>PCT No. PCT/EP94/03154 Sec. 371 Date Jun. 8, 1995 Sec. 102(e) Date Jun. 8, 1995 PCT Filed Sep. 21, 1994 PCT Pub. No. WO95/10304 PCT Pub. Date Apr. 20, 1995A polymeric conjugate consists essentially of: (i) from 60 to 99 mol % of N-(2-hydroxypropyl) methacryloylamide units represented by formula 1: ethacryloylglycyl-aminoacyl) camptothecin units represented by formula 2 2 wherein [A] is a spacer group having respective terminal amino and carbonyl groups which are separated by at least three atoms and O-CPT represents a residue of a camptothecin, the C-20 hydroxy group of the camptothecin being linked to the terminal carbonyl group of the spacer group [A]; and (iii) from 0 to 10 mol % of N-methacryloylglycine or N-(2-hydroxy-propyl)methacryloylglycinamide units represented by formula 3: 3 wherein Z represents hydroxy or a residue of formula -NH-CH2-CH(OH)-CH3.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP
title	Polymerbundne camptothecinderivater
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