ANTIPSYCHOTISCHE INDAZOLDERIVATE

ANTIPSYCHOTISCHE INDAZOLDERIVATE

PCT No. PCT/GB94/00504 Sec. 371 Date Dec. 29, 1995 Sec. 102(e) Date Dec. 29, 1995 PCT Filed Mar. 14, 1994 PCT Pub. No. WO94/21630 PCT Pub. Date Sep. 29, 1994Disclosed is a class of 1H-indazole derivatives, substituted at the 3-position by a substituted piperazinylmethyl moiety, which are antagonists...

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Hauptverfasser: KULAGOWSKI, JANUSZ, JOZEF, HARLOW ESSEX CM20 2QR, GB, LEESON, PAUL, DAVID, HARLOW ESSEX CM20 2QR, GB, SMITH, ADRIAN, LEONARD, HARLOW ESSEX CM20 2QR, GB, BAKER, RAYMOND, ESSEX CM20 2QR, GB
Format: Patent
Sprache:ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:PCT No. PCT/GB94/00504 Sec. 371 Date Dec. 29, 1995 Sec. 102(e) Date Dec. 29, 1995 PCT Filed Mar. 14, 1994 PCT Pub. No. WO94/21630 PCT Pub. Date Sep. 29, 1994Disclosed is a class of 1H-indazole derivatives, substituted at the 3-position by a substituted piperazinylmethyl moiety, which are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopamine D4 receptor subtype over other dopamine receptor subtypes, and are accordingly, of benefit in the treatment and/or prevention of psychotic disorders, such as schizophrenia, while manifesting fewer side-effects than those associated with classical neuroleptic drugs.