SUBSTITUIERTE 1,1,2,-TRIPHENYLBUTENE UND IHRE VERWENDUNG ZUR BEHANDLUNG UND DIAGNOSE VON KREBS
PCT No. PCT/GB93/00889 Sec. 371 Date Jan. 17, 1995 Sec. 102(e) Date Jan. 17, 1995 PCT Filed Apr. 29, 1993 PCT Pub. No. WO93/22275 PCT Pub. Date Nov. 11, 1993Compounds of the general formula (2) (2) wherein n is an integer of from 3 to 10, the iodo substituent is in the 3- or 4-position and R1 and R2...
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| creator | JARMAN, MICHAEL 46 BRODRICK ROAD, LONDON SW17 7DY, GB HARDCASTLE, IAN, ROBERT 25 READING ROAD, SURREY SM1 4RW, GB NEIDLE, STEPHEN RAINBOW'S END RAINBOW COURT, HERTFORDSHIRE WD1 4RP, GB EDWARDS, KAREN, JENNIFER, HILLCREST NATAL 3610, ZA LAUGHTON, CHARLES, ANTHONY 12 VICTORIA ROAD, SURREY SM1 4RT, GB |
| description | PCT No. PCT/GB93/00889 Sec. 371 Date Jan. 17, 1995 Sec. 102(e) Date Jan. 17, 1995 PCT Filed Apr. 29, 1993 PCT Pub. No. WO93/22275 PCT Pub. Date Nov. 11, 1993Compounds of the general formula (2) (2) wherein n is an integer of from 3 to 10, the iodo substituent is in the 3- or 4-position and R1 and R2, which may be the same or different, represent C1-3 alkyl, especially methyl or ethyl, groups or Rl represents a hydrogen atom and R2 a C1-3 alkyl group or R1 and R2 together with the nitrogen atom to which they are attached represent a saturated heterocyclic group, especially a pyrrolidino group, in the form of their free bases or pharmaceutically acceptable acid addition salts are potent anti-oestrogenic compounds useful for treatment of oestrogen-dependent cancers, especially breast cancers. Compounds where the iodine atom is radioisotopic are useful in radiotherapy or gamma ray imaging of these cancers. |
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No. WO93/22275 PCT Pub. Date Nov. 11, 1993Compounds of the general formula (2) (2) wherein n is an integer of from 3 to 10, the iodo substituent is in the 3- or 4-position and R1 and R2, which may be the same or different, represent C1-3 alkyl, especially methyl or ethyl, groups or Rl represents a hydrogen atom and R2 a C1-3 alkyl group or R1 and R2 together with the nitrogen atom to which they are attached represent a saturated heterocyclic group, especially a pyrrolidino group, in the form of their free bases or pharmaceutically acceptable acid addition salts are potent anti-oestrogenic compounds useful for treatment of oestrogen-dependent cancers, especially breast cancers. 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No. WO93/22275 PCT Pub. Date Nov. 11, 1993Compounds of the general formula (2) (2) wherein n is an integer of from 3 to 10, the iodo substituent is in the 3- or 4-position and R1 and R2, which may be the same or different, represent C1-3 alkyl, especially methyl or ethyl, groups or Rl represents a hydrogen atom and R2 a C1-3 alkyl group or R1 and R2 together with the nitrogen atom to which they are attached represent a saturated heterocyclic group, especially a pyrrolidino group, in the form of their free bases or pharmaceutically acceptable acid addition salts are potent anti-oestrogenic compounds useful for treatment of oestrogen-dependent cancers, especially breast cancers. 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No. WO93/22275 PCT Pub. Date Nov. 11, 1993Compounds of the general formula (2) (2) wherein n is an integer of from 3 to 10, the iodo substituent is in the 3- or 4-position and R1 and R2, which may be the same or different, represent C1-3 alkyl, especially methyl or ethyl, groups or Rl represents a hydrogen atom and R2 a C1-3 alkyl group or R1 and R2 together with the nitrogen atom to which they are attached represent a saturated heterocyclic group, especially a pyrrolidino group, in the form of their free bases or pharmaceutically acceptable acid addition salts are potent anti-oestrogenic compounds useful for treatment of oestrogen-dependent cancers, especially breast cancers. Compounds where the iodine atom is radioisotopic are useful in radiotherapy or gamma ray imaging of these cancers.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SUBSTITUIERTE 1,1,2,-TRIPHENYLBUTENE UND IHRE VERWENDUNG ZUR BEHANDLUNG UND DIAGNOSE VON KREBS |
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