ZIELGERICHTETE SPEZIFISCHE ANTIKÖRPER-SUPERANTIGEN KONJUGATE UND IHRE PRÄPARATION

A soluble antibody conjugate comprising an antibody linked to a structure which is recognizable by T-cells and has the ability to direct T-cells to lyse the target cell, which is recognized by the antibody. The conjugate is characterized by the structure being a superantigen. One important mode is a...

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Hauptverfasser: KERBLOM, EVA, S-752 52 UPPSALA, SE, KALLAND, TERJE, S-240 21 LOEDDEKOEPING, SE, DOHLSTEN, MIKAEL, S-223 52 LUND, SE, LANDO, PETER, S-214 34 MALMOE, SE, HEDLUND, GUNNAR, S-223 51 LUND, SE
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creator KERBLOM, EVA, S-752 52 UPPSALA, SE
KALLAND, TERJE, S-240 21 LOEDDEKOEPING, SE
DOHLSTEN, MIKAEL, S-223 52 LUND, SE
LANDO, PETER, S-214 34 MALMOE, SE
HEDLUND, GUNNAR, S-223 51 LUND, SE
description A soluble antibody conjugate comprising an antibody linked to a structure which is recognizable by T-cells and has the ability to direct T-cells to lyse the target cell, which is recognized by the antibody. The conjugate is characterized by the structure being a superantigen. One important mode is a method for the lysis of target cells, wherein the target cells are contacted with a target cell lysis effective amount of the conjugate. The method of lysis is part of a potent treatment regimen for cancer, autoimmunity, parasitic infestations and fungal, viral and bacterial infections. The specification also describes modes such as the synthesis of the conjugate and pharmaceutical compositions and their manufacture.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title ZIELGERICHTETE SPEZIFISCHE ANTIKÖRPER-SUPERANTIGEN KONJUGATE UND IHRE PRÄPARATION
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