Gen-Sequenzentransfer und -exprimierung bei Zellen des zentralen Nervensystems mit mutierenden Herpes-Simplex-Viren, die Deletionen in Viren-Replikationsgenen enthalten

Methods of gene delivery to cells in the central nervous system are disclosed by introducing and expressing gene sequences mediated by herpes simplex virus 1 (HSV-1) vectors with a mutation in a gene for viral replication.

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Bibliographische Detailangaben
Hauptverfasser:	MARTUZA, ROBERT L., LEXINGTON, MASSACHUSETTS 02173, US, BREAKFIELD, , XANDRA O., NEWTON, MASSACHUSETTS 02159, US
Format:	Patent
Sprache:	ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Methods of gene delivery to cells in the central nervous system are disclosed by introducing and expressing gene sequences mediated by herpes simplex virus 1 (HSV-1) vectors with a mutation in a gene for viral replication.