ANHÄUFUNG VON AMINOSÄUREN UND PEPTIDEN IN LIPOSOMEN
The present invention relates to liposomal compositions having a concentration gradient which load amino acids and peptides exhibiting weak acid or base characteristics into liposomes. Specifically loaded into liposomes by the methods of the present invention are C-terminal substituted amino acids o...
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| creator | CHAKRABARTI, AJOY, VANCOUVER, BRITISH COLUMBIA V6R 2R4, CA CULLIS, PIETER, R., VANCOUVER, BRITISH COLUMBIA V6R 1H4, CA CLARK-LEWIS, IAN, VANCOUVER, BRITISH COLUMBIA V6R 2P9, CA |
| description | The present invention relates to liposomal compositions having a concentration gradient which load amino acids and peptides exhibiting weak acid or base characteristics into liposomes. Specifically loaded into liposomes by the methods of the present invention are C-terminal substituted amino acids or peptides. The liposomes are preferably large unilamellar vesicles. The concentration gradient is formed by encapsulating a first medium in the liposomes, said medium having a first concentration of the one or more charged species, and suspending the liposomes in a second medium having a second concentration of the one or more charged species, such as for example a pH gradient. Also disclosed are pharmaceutical preparations comprising such C-terminal substituted amino acids or peptides which have been loaded into the liposomes by the method of the invention. |
| format | Patent |
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Specifically loaded into liposomes by the methods of the present invention are C-terminal substituted amino acids or peptides. The liposomes are preferably large unilamellar vesicles. The concentration gradient is formed by encapsulating a first medium in the liposomes, said medium having a first concentration of the one or more charged species, and suspending the liposomes in a second medium having a second concentration of the one or more charged species, such as for example a pH gradient. Also disclosed are pharmaceutical preparations comprising such C-terminal substituted amino acids or peptides which have been loaded into the liposomes by the method of the invention.</description><edition>6</edition><language>ger</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>1996</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19961212&DB=EPODOC&CC=DE&NR=69120089T2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19961212&DB=EPODOC&CC=DE&NR=69120089T2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHAKRABARTI, AJOY, VANCOUVER, BRITISH COLUMBIA V6R 2R4, CA</creatorcontrib><creatorcontrib>CULLIS, PIETER, R., VANCOUVER, BRITISH COLUMBIA V6R 1H4, CA</creatorcontrib><creatorcontrib>CLARK-LEWIS, IAN, VANCOUVER, BRITISH COLUMBIA V6R 2P9, CA</creatorcontrib><title>ANHÄUFUNG VON AMINOSÄUREN UND PEPTIDEN IN LIPOSOMEN</title><description>The present invention relates to liposomal compositions having a concentration gradient which load amino acids and peptides exhibiting weak acid or base characteristics into liposomes. Specifically loaded into liposomes by the methods of the present invention are C-terminal substituted amino acids or peptides. The liposomes are preferably large unilamellar vesicles. The concentration gradient is formed by encapsulating a first medium in the liposomes, said medium having a first concentration of the one or more charged species, and suspending the liposomes in a second medium having a second concentration of the one or more charged species, such as for example a pH gradient. Also disclosed are pharmaceutical preparations comprising such C-terminal substituted amino acids or peptides which have been loaded into the liposomes by the method of the invention.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1996</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDB19PM43BLqFurnrhDm76fg6Ovp5x8MFAly9VMI9XNRCHANCPF0AXI8_RR8PAP8g_19Xf14GFjTEnOKU3mhNDeDkptriLOHbmpBfnxqcUFicmpeakm8i6uZpaGRgYGFZUiIkTFRigAWoCoR</recordid><startdate>19961212</startdate><enddate>19961212</enddate><creator>CHAKRABARTI, AJOY, VANCOUVER, BRITISH COLUMBIA V6R 2R4, CA</creator><creator>CULLIS, PIETER, R., VANCOUVER, BRITISH COLUMBIA V6R 1H4, CA</creator><creator>CLARK-LEWIS, IAN, VANCOUVER, BRITISH COLUMBIA V6R 2P9, CA</creator><scope>EVB</scope></search><sort><creationdate>19961212</creationdate><title>ANHÄUFUNG VON AMINOSÄUREN UND PEPTIDEN IN LIPOSOMEN</title><author>CHAKRABARTI, AJOY, VANCOUVER, BRITISH COLUMBIA V6R 2R4, CA ; CULLIS, PIETER, R., VANCOUVER, BRITISH COLUMBIA V6R 1H4, CA ; CLARK-LEWIS, IAN, VANCOUVER, BRITISH COLUMBIA V6R 2P9, CA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_DE69120089TT23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>ger</language><creationdate>1996</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>CHAKRABARTI, AJOY, VANCOUVER, BRITISH COLUMBIA V6R 2R4, CA</creatorcontrib><creatorcontrib>CULLIS, PIETER, R., VANCOUVER, BRITISH COLUMBIA V6R 1H4, CA</creatorcontrib><creatorcontrib>CLARK-LEWIS, IAN, VANCOUVER, BRITISH COLUMBIA V6R 2P9, CA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHAKRABARTI, AJOY, VANCOUVER, BRITISH COLUMBIA V6R 2R4, CA</au><au>CULLIS, PIETER, R., VANCOUVER, BRITISH COLUMBIA V6R 1H4, CA</au><au>CLARK-LEWIS, IAN, VANCOUVER, BRITISH COLUMBIA V6R 2P9, CA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANHÄUFUNG VON AMINOSÄUREN UND PEPTIDEN IN LIPOSOMEN</title><date>1996-12-12</date><risdate>1996</risdate><abstract>The present invention relates to liposomal compositions having a concentration gradient which load amino acids and peptides exhibiting weak acid or base characteristics into liposomes. Specifically loaded into liposomes by the methods of the present invention are C-terminal substituted amino acids or peptides. The liposomes are preferably large unilamellar vesicles. The concentration gradient is formed by encapsulating a first medium in the liposomes, said medium having a first concentration of the one or more charged species, and suspending the liposomes in a second medium having a second concentration of the one or more charged species, such as for example a pH gradient. Also disclosed are pharmaceutical preparations comprising such C-terminal substituted amino acids or peptides which have been loaded into the liposomes by the method of the invention.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | ANHÄUFUNG VON AMINOSÄUREN UND PEPTIDEN IN LIPOSOMEN |
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