QUINOLONCARBONSÄUREDERIVAT

A quinolonecarboxylic acid derivative represented by general formula (1), its salt and an antibacterial agent containing the same as the active ingredient, wherein R represents hydrogen, alkyl, aralkyl or an ester residue which is hydrolyzable in vivo; R represents hydrogen or amino which may be sub...

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Hauptverfasser: TAIDO, NAOKATA, CHIBA 274, JP, TAKEDA, SUNAO, ICHIHARA-SHI, CHIBA 290, JP, MATSUDA, HIDEAKI, ABIKO-SHI, CHIBA 270-01, JP, KAWAHARA, RYUICHI, CHIBA 272, JP, KONNO, FUJIKO, INBA-GUN, CHIBA 286-02, JP, KURAISHI, TADAYUKI, CHIBA-SHI, CHIBA 281, JP, SHIBATA, AKIHIRO, YACHIYO-SHI, CHIBA 276, JP, ASAOKA, TAKEMITSU, NARITA-SHI, CHIBA 286, JP
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creator TAIDO, NAOKATA, CHIBA 274, JP
TAKEDA, SUNAO, ICHIHARA-SHI, CHIBA 290, JP
MATSUDA, HIDEAKI, ABIKO-SHI, CHIBA 270-01, JP
KAWAHARA, RYUICHI, CHIBA 272, JP
KONNO, FUJIKO, INBA-GUN, CHIBA 286-02, JP
KURAISHI, TADAYUKI, CHIBA-SHI, CHIBA 281, JP
SHIBATA, AKIHIRO, YACHIYO-SHI, CHIBA 276, JP
ASAOKA, TAKEMITSU, NARITA-SHI, CHIBA 286, JP
description A quinolonecarboxylic acid derivative represented by general formula (1), its salt and an antibacterial agent containing the same as the active ingredient, wherein R represents hydrogen, alkyl, aralkyl or an ester residue which is hydrolyzable in vivo; R represents hydrogen or amino which may be substituted with one or two lower alkyl groups; X represents hydrogen or halogen; Y represents CH2, O, S, SO, SO2 or NR , wherein R represents hydrogen or lower alkyl; and Z represents an oxygen atom or two hydrogen atoms. This compound develops a potent antibacterial activity particularly against gram-positive bacteria, so that it is useful in preventing and treating various infectious diseases clinically.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title QUINOLONCARBONSÄUREDERIVAT
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