TRIAZOLDERIVATE ALS TACHYKININREZEPTOR-ANTAGONISTEN
This application relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and its use as an inhibitor of the NK-1 subtype of tachykinin receptors, as well as a process for its preparation and intermediates therefor. (I) wherein: D is a...
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| creator | GARDINIER, KEVIN MATTHEW HONG, JIAN ERIC JUNGHEIM, LOUIS NICKOLAUS ROBERTSON, MICHAEL ALAN SAVIN, KENNETH ALLEN AMEGADZIE, ALBERT KUDZOVI HEMBRE, ERIK JAMES REMICK, DAVID MICHAEL MUEHL, BRIAN STEPHEN |
| description | This application relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and its use as an inhibitor of the NK-1 subtype of tachykinin receptors, as well as a process for its preparation and intermediates therefor. (I) wherein: D is a C1-C3 alkane-diyl; R1 is phenyl, which is optionally substituted with one to three substitutents independently selected from the group consisting of halo, C1-C4 alkyl, C1-C4 alkoxy, cyano, difluoromethyl, trifluoromethyl, and trifluoromethoxy; R4 is a radical selected from the group consisting of: (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH) |
| format | Patent |
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(I) wherein: D is a C1-C3 alkane-diyl; R1 is phenyl, which is optionally substituted with one to three substitutents independently selected from the group consisting of halo, C1-C4 alkyl, C1-C4 alkoxy, cyano, difluoromethyl, trifluoromethyl, and trifluoromethoxy; R4 is a radical selected from the group consisting of: (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH)</description><language>ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2009</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090108&DB=EPODOC&CC=DE&NR=60318697T2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090108&DB=EPODOC&CC=DE&NR=60318697T2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GARDINIER, KEVIN MATTHEW</creatorcontrib><creatorcontrib>HONG, JIAN ERIC</creatorcontrib><creatorcontrib>JUNGHEIM, LOUIS NICKOLAUS</creatorcontrib><creatorcontrib>ROBERTSON, MICHAEL ALAN</creatorcontrib><creatorcontrib>SAVIN, KENNETH ALLEN</creatorcontrib><creatorcontrib>AMEGADZIE, ALBERT KUDZOVI</creatorcontrib><creatorcontrib>HEMBRE, ERIK JAMES</creatorcontrib><creatorcontrib>REMICK, DAVID MICHAEL</creatorcontrib><creatorcontrib>MUEHL, BRIAN STEPHEN</creatorcontrib><title>TRIAZOLDERIVATE ALS TACHYKININREZEPTOR-ANTAGONISTEN</title><description>This application relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and its use as an inhibitor of the NK-1 subtype of tachykinin receptors, as well as a process for its preparation and intermediates therefor. (I) wherein: D is a C1-C3 alkane-diyl; R1 is phenyl, which is optionally substituted with one to three substitutents independently selected from the group consisting of halo, C1-C4 alkyl, C1-C4 alkoxy, cyano, difluoromethyl, trifluoromethyl, and trifluoromethoxy; R4 is a radical selected from the group consisting of: (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH)</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2009</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAOCfJ0jPL3cXEN8gxzDHFVcPQJVghxdPaI9Pb08_QLco1yDQjxD9J19AtxdPf38wwOcfXjYWBNS8wpTuWF0twMSm6uIc4euqkF-fGpxQWJyal5qSXxLq5mBsaGFmaW5iEhRsZEKQIASoUorA</recordid><startdate>20090108</startdate><enddate>20090108</enddate><creator>GARDINIER, KEVIN MATTHEW</creator><creator>HONG, JIAN ERIC</creator><creator>JUNGHEIM, LOUIS NICKOLAUS</creator><creator>ROBERTSON, MICHAEL ALAN</creator><creator>SAVIN, KENNETH ALLEN</creator><creator>AMEGADZIE, ALBERT KUDZOVI</creator><creator>HEMBRE, ERIK JAMES</creator><creator>REMICK, DAVID MICHAEL</creator><creator>MUEHL, BRIAN STEPHEN</creator><scope>EVB</scope></search><sort><creationdate>20090108</creationdate><title>TRIAZOLDERIVATE ALS TACHYKININREZEPTOR-ANTAGONISTEN</title><author>GARDINIER, KEVIN MATTHEW ; HONG, JIAN ERIC ; JUNGHEIM, LOUIS NICKOLAUS ; ROBERTSON, MICHAEL ALAN ; SAVIN, KENNETH ALLEN ; AMEGADZIE, ALBERT KUDZOVI ; HEMBRE, ERIK JAMES ; REMICK, DAVID MICHAEL ; MUEHL, BRIAN STEPHEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_DE60318697TT23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>ger</language><creationdate>2009</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GARDINIER, KEVIN MATTHEW</creatorcontrib><creatorcontrib>HONG, JIAN ERIC</creatorcontrib><creatorcontrib>JUNGHEIM, LOUIS NICKOLAUS</creatorcontrib><creatorcontrib>ROBERTSON, MICHAEL ALAN</creatorcontrib><creatorcontrib>SAVIN, KENNETH ALLEN</creatorcontrib><creatorcontrib>AMEGADZIE, ALBERT KUDZOVI</creatorcontrib><creatorcontrib>HEMBRE, ERIK JAMES</creatorcontrib><creatorcontrib>REMICK, DAVID MICHAEL</creatorcontrib><creatorcontrib>MUEHL, BRIAN STEPHEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GARDINIER, KEVIN MATTHEW</au><au>HONG, JIAN ERIC</au><au>JUNGHEIM, LOUIS NICKOLAUS</au><au>ROBERTSON, MICHAEL ALAN</au><au>SAVIN, KENNETH ALLEN</au><au>AMEGADZIE, ALBERT KUDZOVI</au><au>HEMBRE, ERIK JAMES</au><au>REMICK, DAVID MICHAEL</au><au>MUEHL, BRIAN STEPHEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>TRIAZOLDERIVATE ALS TACHYKININREZEPTOR-ANTAGONISTEN</title><date>2009-01-08</date><risdate>2009</risdate><abstract>This application relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and its use as an inhibitor of the NK-1 subtype of tachykinin receptors, as well as a process for its preparation and intermediates therefor. (I) wherein: D is a C1-C3 alkane-diyl; R1 is phenyl, which is optionally substituted with one to three substitutents independently selected from the group consisting of halo, C1-C4 alkyl, C1-C4 alkoxy, cyano, difluoromethyl, trifluoromethyl, and trifluoromethoxy; R4 is a radical selected from the group consisting of: (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH)</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | TRIAZOLDERIVATE ALS TACHYKININREZEPTOR-ANTAGONISTEN |
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