TOR-ANTAGONISTEN
The present invention relates to compounds of formula I: wherein one of R1 and R4 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, and phenyl-C1-4 alkyl; and the other of R1 and R4 is an optionally substituted C9-14 aryl...
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| creator | OXFORD, ALEXANDER WILLIAM BORMAN, RICHARD ANTHONY HYND, GEORGE ARCHER, JANET ANN ALEY, AMANDA CLARK, KENNETH LYLE HARRIS, NEIL VICTOR COLEMAN, ROBERT ALEXANDER |
| description | The present invention relates to compounds of formula I: wherein one of R1 and R4 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, and phenyl-C1-4 alkyl; and the other of R1 and R4 is an optionally substituted C9-14 aryl group; R2 and R3 are either: (i) independently selected from H, R, R', SO2R, C(-O)R, (CH2)nNR5R6, where n is from 1 to 4 and R5 and R6 are independently selected from H and R, where R is optionally substituted C1-4 alkyl, and R' is optionally substituted phenyl-C1-4 alkyl, or (ii) together with the nitrogen atom to which they are attached, form an optionally substituted C5-7 heterocyclic group; and their use as pharmaceuticals, in particular for treating conditions alleviated by the antagonism of a 5-HT2B receptor. |
| format | Patent |
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and the other of R1 and R4 is an optionally substituted C9-14 aryl group; R2 and R3 are either: (i) independently selected from H, R, R', SO2R, C(-O)R, (CH2)nNR5R6, where n is from 1 to 4 and R5 and R6 are independently selected from H and R, where R is optionally substituted C1-4 alkyl, and R' is optionally substituted phenyl-C1-4 alkyl, or (ii) together with the nitrogen atom to which they are attached, form an optionally substituted C5-7 heterocyclic group; and their use as pharmaceuticals, in particular for treating conditions alleviated by the antagonism of a 5-HT2B receptor.</description><language>ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20081030&DB=EPODOC&CC=DE&NR=60317632T2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20081030&DB=EPODOC&CC=DE&NR=60317632T2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>OXFORD, ALEXANDER WILLIAM</creatorcontrib><creatorcontrib>BORMAN, RICHARD ANTHONY</creatorcontrib><creatorcontrib>HYND, GEORGE</creatorcontrib><creatorcontrib>ARCHER, JANET ANN</creatorcontrib><creatorcontrib>ALEY, AMANDA</creatorcontrib><creatorcontrib>CLARK, KENNETH LYLE</creatorcontrib><creatorcontrib>HARRIS, NEIL VICTOR</creatorcontrib><creatorcontrib>COLEMAN, ROBERT ALEXANDER</creatorcontrib><title>TOR-ANTAGONISTEN</title><description>The present invention relates to compounds of formula I: wherein one of R1 and R4 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, and phenyl-C1-4 alkyl; and the other of R1 and R4 is an optionally substituted C9-14 aryl group; R2 and R3 are either: (i) independently selected from H, R, R', SO2R, C(-O)R, (CH2)nNR5R6, where n is from 1 to 4 and R5 and R6 are independently selected from H and R, where R is optionally substituted C1-4 alkyl, and R' is optionally substituted phenyl-C1-4 alkyl, or (ii) together with the nitrogen atom to which they are attached, form an optionally substituted C5-7 heterocyclic group; and their use as pharmaceuticals, in particular for treating conditions alleviated by the antagonism of a 5-HT2B receptor.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBAI8Q_SdfQLcXT39_MMDnH142FgTUvMKU7lhdLcDEpuriHOHrqpBfnxqcUFicmpeakl8S6uZgbGhuZmxkYhIUbGRCkCAFC3HmA</recordid><startdate>20081030</startdate><enddate>20081030</enddate><creator>OXFORD, ALEXANDER WILLIAM</creator><creator>BORMAN, RICHARD ANTHONY</creator><creator>HYND, GEORGE</creator><creator>ARCHER, JANET ANN</creator><creator>ALEY, AMANDA</creator><creator>CLARK, KENNETH LYLE</creator><creator>HARRIS, NEIL VICTOR</creator><creator>COLEMAN, ROBERT ALEXANDER</creator><scope>EVB</scope></search><sort><creationdate>20081030</creationdate><title>TOR-ANTAGONISTEN</title><author>OXFORD, ALEXANDER WILLIAM ; BORMAN, RICHARD ANTHONY ; HYND, GEORGE ; ARCHER, JANET ANN ; ALEY, AMANDA ; CLARK, KENNETH LYLE ; HARRIS, NEIL VICTOR ; COLEMAN, ROBERT ALEXANDER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_DE60317632TT23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>ger</language><creationdate>2008</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>OXFORD, ALEXANDER WILLIAM</creatorcontrib><creatorcontrib>BORMAN, RICHARD ANTHONY</creatorcontrib><creatorcontrib>HYND, GEORGE</creatorcontrib><creatorcontrib>ARCHER, JANET ANN</creatorcontrib><creatorcontrib>ALEY, AMANDA</creatorcontrib><creatorcontrib>CLARK, KENNETH LYLE</creatorcontrib><creatorcontrib>HARRIS, NEIL VICTOR</creatorcontrib><creatorcontrib>COLEMAN, ROBERT ALEXANDER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>OXFORD, ALEXANDER WILLIAM</au><au>BORMAN, RICHARD ANTHONY</au><au>HYND, GEORGE</au><au>ARCHER, JANET ANN</au><au>ALEY, AMANDA</au><au>CLARK, KENNETH LYLE</au><au>HARRIS, NEIL VICTOR</au><au>COLEMAN, ROBERT ALEXANDER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>TOR-ANTAGONISTEN</title><date>2008-10-30</date><risdate>2008</risdate><abstract>The present invention relates to compounds of formula I: wherein one of R1 and R4 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, and phenyl-C1-4 alkyl; and the other of R1 and R4 is an optionally substituted C9-14 aryl group; R2 and R3 are either: (i) independently selected from H, R, R', SO2R, C(-O)R, (CH2)nNR5R6, where n is from 1 to 4 and R5 and R6 are independently selected from H and R, where R is optionally substituted C1-4 alkyl, and R' is optionally substituted phenyl-C1-4 alkyl, or (ii) together with the nitrogen atom to which they are attached, form an optionally substituted C5-7 heterocyclic group; and their use as pharmaceuticals, in particular for treating conditions alleviated by the antagonism of a 5-HT2B receptor.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | TOR-ANTAGONISTEN |
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