Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor
The invention concerns a process for extracting high-purity von Willebrand factor wherein recombinant von Willebrand factor (rvWF) is chromatographically purified by anion exchange chromatography on a quaternary amino-type anion exchanger in a buffer solution comprising buffer substances and optiona...
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| creator | FISCHER, BERNHARD., WIEN, AT DORNER, FRIEDRICH, DR., WIEN, AT MITTERER, ARTUR., ORTH, AT |
| description | The invention concerns a process for extracting high-purity von Willebrand factor wherein recombinant von Willebrand factor (rvWF) is chromatographically purified by anion exchange chromatography on a quaternary amino-type anion exchanger in a buffer solution comprising buffer substances and optionally salt. The buffer solutions are preferably free from stabilizers, amino acids and other additives. This process produces high-purity recombinant vWF which is free from blood plasma proteins, in particular factor VIII, and is physiologically active. The invention further concerns a pharmaceutical preparation which contains rvWF and is composed of multimers having high structural integrity. |
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The buffer solutions are preferably free from stabilizers, amino acids and other additives. This process produces high-purity recombinant vWF which is free from blood plasma proteins, in particular factor VIII, and is physiologically active. 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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor |
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