N-ACYL-N-NAPHTHOYLGLYCINE ALS ALDOSE-REDUCTASE-INHIBITOREN

N-ACYL-N-NAPHTHOYLGLYCINE ALS ALDOSE-REDUCTASE-INHIBITOREN

Disclosed herein are N-naphthoylglycines and methods of their preparation. The N-naphthoylglycines are novel aldose reductase inhibitors useful for the treatment or prevention of diabetic complications and have the formula wherein R is fluorine, chlorine, bromine, lower alkoxy containing 1 to 5 carb...

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Hauptverfasser: WROBEL, JAY E., LAWRENCEVILLE NEW JERSEY 08648, US, BAUMAN, JOHN G., E. WINDSOR NEW JERSEY 08520, US, SESTANJ, KAZIMIR, MONMOUTH JUNCTION NEW JERSEY 08852, US
Format: Patent
Sprache:ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Disclosed herein are N-naphthoylglycines and methods of their preparation. The N-naphthoylglycines are novel aldose reductase inhibitors useful for the treatment or prevention of diabetic complications and have the formula wherein R is fluorine, chlorine, bromine, lower alkoxy containing 1 to 5 carbon atoms, trifluoroethoxy, phenoxy or phenylmethoxy; X is =O, or =S; Y is -OH, -NH2 or -NHCO2CH2CH3, and the pharmaceutically acceptable salts thereof.