5-Fluoro-Uracil-Derivate
This invention relates to a 5-fluorouracil derivative represented by the formula wherein R is a hydrogen atom or a specific acyl group, Z is a phenyl-lower alkoxy-lower alkyl group, thienyl-lower alkyl group optionally substituted with halogen atom on the thienyl ring, or a group wherein R and R are...
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| creator | YAMAMOTO, YOSHIHITO, OOTSU-SHI SHIGA-KEN, JP KOJIMA, YUTAKA, OOTSU-SHI SHIGA-KEN, JP FUJII, SETSURO AIG DE BLANCHE 703, NAKAGYO-KU KYOTO-SHI KYOTO-FU, JP HIROHASHI, MITSURU, OOTSU-SHI SHIGA-KEN, JP |
| description | This invention relates to a 5-fluorouracil derivative represented by the formula wherein R is a hydrogen atom or a specific acyl group, Z is a phenyl-lower alkoxy-lower alkyl group, thienyl-lower alkyl group optionally substituted with halogen atom on the thienyl ring, or a group wherein R and R are each a hydrogen atom, a specific acyl group, phenyl-lower alkyl group having a group ROCO- on the phenyl ring, or a group -(A)nB, R fix being a specific organic group, A being a lower alkylene group, n being 0 or 1, and B being a 5- or 6-membered unsaturated heterocyclic group having 1 to 4 hetero-atoms selected from nitrogen, oxygen and sulfur and optionally having a benzene ring, naphthalene ring or pyridine ring condensed therewith, with the proviso that when R is a hydrogen atom or acyl group, R is not a hydrogen atom or acyl group; to a process for preparing the same; to an anticancer composition comprising an effective amounts of the same; and to use of the same for preparation of an anticancer composition. |
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HIROHASHI, MITSURU, OOTSU-SHI SHIGA-KEN, JP</creatorcontrib><description>This invention relates to a 5-fluorouracil derivative represented by the formula wherein R is a hydrogen atom or a specific acyl group, Z is a phenyl-lower alkoxy-lower alkyl group, thienyl-lower alkyl group optionally substituted with halogen atom on the thienyl ring, or a group wherein R and R are each a hydrogen atom, a specific acyl group, phenyl-lower alkyl group having a group ROCO- on the phenyl ring, or a group -(A)nB, R fix being a specific organic group, A being a lower alkylene group, n being 0 or 1, and B being a 5- or 6-membered unsaturated heterocyclic group having 1 to 4 hetero-atoms selected from nitrogen, oxygen and sulfur and optionally having a benzene ring, naphthalene ring or pyridine ring condensed therewith, with the proviso that when R is a hydrogen atom or acyl group, R is not a hydrogen atom or acyl group; to a process for preparing the same; to an anticancer composition comprising an effective amounts of the same; and to use of the same for preparation of an anticancer composition.</description><edition>5</edition><language>ger</language><subject>BASIC ELECTRIC ELEMENTS ; CHEMISTRY ; DERIVATIVES THEREOF ; DEVICES USING STIMULATED EMISSION ; ELECTRICITY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SUGARS</subject><creationdate>1994</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19940303&DB=EPODOC&CC=DE&NR=3786834T2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19940303&DB=EPODOC&CC=DE&NR=3786834T2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YAMAMOTO, YOSHIHITO, OOTSU-SHI SHIGA-KEN, JP</creatorcontrib><creatorcontrib>KOJIMA, YUTAKA, OOTSU-SHI SHIGA-KEN, JP</creatorcontrib><creatorcontrib>FUJII, SETSURO AIG DE BLANCHE 703, NAKAGYO-KU KYOTO-SHI KYOTO-FU, JP</creatorcontrib><creatorcontrib>HIROHASHI, MITSURU, OOTSU-SHI SHIGA-KEN, JP</creatorcontrib><title>5-Fluoro-Uracil-Derivate</title><description>This invention relates to a 5-fluorouracil derivative represented by the formula wherein R is a hydrogen atom or a specific acyl group, Z is a phenyl-lower alkoxy-lower alkyl group, thienyl-lower alkyl group optionally substituted with halogen atom on the thienyl ring, or a group wherein R and R are each a hydrogen atom, a specific acyl group, phenyl-lower alkyl group having a group ROCO- on the phenyl ring, or a group -(A)nB, R fix being a specific organic group, A being a lower alkylene group, n being 0 or 1, and B being a 5- or 6-membered unsaturated heterocyclic group having 1 to 4 hetero-atoms selected from nitrogen, oxygen and sulfur and optionally having a benzene ring, naphthalene ring or pyridine ring condensed therewith, with the proviso that when R is a hydrogen atom or acyl group, R is not a hydrogen atom or acyl group; 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KOJIMA, YUTAKA, OOTSU-SHI SHIGA-KEN, JP ; FUJII, SETSURO AIG DE BLANCHE 703, NAKAGYO-KU KYOTO-SHI KYOTO-FU, JP ; HIROHASHI, MITSURU, OOTSU-SHI SHIGA-KEN, JP</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_DE3786834TT23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>ger</language><creationdate>1994</creationdate><topic>BASIC ELECTRIC ELEMENTS</topic><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>DEVICES USING STIMULATED EMISSION</topic><topic>ELECTRICITY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>YAMAMOTO, YOSHIHITO, OOTSU-SHI SHIGA-KEN, JP</creatorcontrib><creatorcontrib>KOJIMA, YUTAKA, OOTSU-SHI SHIGA-KEN, JP</creatorcontrib><creatorcontrib>FUJII, SETSURO AIG DE BLANCHE 703, NAKAGYO-KU KYOTO-SHI KYOTO-FU, JP</creatorcontrib><creatorcontrib>HIROHASHI, MITSURU, OOTSU-SHI SHIGA-KEN, JP</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YAMAMOTO, YOSHIHITO, OOTSU-SHI SHIGA-KEN, JP</au><au>KOJIMA, YUTAKA, OOTSU-SHI SHIGA-KEN, JP</au><au>FUJII, SETSURO AIG DE BLANCHE 703, NAKAGYO-KU KYOTO-SHI KYOTO-FU, JP</au><au>HIROHASHI, MITSURU, OOTSU-SHI SHIGA-KEN, JP</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>5-Fluoro-Uracil-Derivate</title><date>1994-03-03</date><risdate>1994</risdate><abstract>This invention relates to a 5-fluorouracil derivative represented by the formula wherein R is a hydrogen atom or a specific acyl group, Z is a phenyl-lower alkoxy-lower alkyl group, thienyl-lower alkyl group optionally substituted with halogen atom on the thienyl ring, or a group wherein R and R are each a hydrogen atom, a specific acyl group, phenyl-lower alkyl group having a group ROCO- on the phenyl ring, or a group -(A)nB, R fix being a specific organic group, A being a lower alkylene group, n being 0 or 1, and B being a 5- or 6-membered unsaturated heterocyclic group having 1 to 4 hetero-atoms selected from nitrogen, oxygen and sulfur and optionally having a benzene ring, naphthalene ring or pyridine ring condensed therewith, with the proviso that when R is a hydrogen atom or acyl group, R is not a hydrogen atom or acyl group; to a process for preparing the same; to an anticancer composition comprising an effective amounts of the same; and to use of the same for preparation of an anticancer composition.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BASIC ELECTRIC ELEMENTS CHEMISTRY DERIVATIVES THEREOF DEVICES USING STIMULATED EMISSION ELECTRICITY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SUGARS |
| title | 5-Fluoro-Uracil-Derivate |
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