NEUE KONDENSIERTE DIAZEPINONE, VERFAHREN ZU IHRER HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL

Condensed diazepinones of the general formula I in which represents one of the divalent radicals and X , X , A, R to R and Z have the following meanings: X and X represent a = CH-group or, if assumes the meanings of the abovementioned divalent radicals (S), (U) or (W), both or only X or only X can also represent a nitrogen atom; A is an alkylene radical having two to seven carbon atoms; which can also be interrupted by an oxygen or sulphur atom or by the methylimino or ethylimino group; Z is a single bond, an oxygen or sulphur atom, the methylene or 1,2-ethylene group; R is a lower alkyl radical or the benzyl group; R is an alkyl radical having 1 to 7 carbon atoms, which can optionally be further substituted by a hydroxyl group on its 2nd to 7th carbon atom, a cycloalkyl or a cycloalkylmethyl radical, where the cycloalkyl ring can optionally be further substituted by a hydroxyl group; R and R , however, together with the nitrogen atom lying in between, can also form a 4- to 7-membered saturated, monocyclic heterocyclic ring which can optionally be interrupted by an oxygen atom or by the N-CH3 group; R can, however, also be linked to A via an alkylene bridge such that, together with the group NR , a saturated, 5 to 7-membered heterocyclic ring system is formed; R is a lower alkyl group, a chlorine atom or a hydrogen atom; R is a hydrogen atom or a methyl group; R and R each denote a hydrogen atom, a fluorine, chlorine or bromine atom or a lower alkyl group; R is a hydrogen or chlorine atom or a methyl group; R is a hydrogen atom or a lower alkyl radical; R is a hydrogen or halogen atom or a lower alkyl group and R is a hydrogen atom or a methyl group, where in the case in which represents the divalent radical (T) and R is hydrogen, R cannot be chlorine and Z cannot be sulphur. Processes for their preparation and medicaments which contain these compounds are also described. In view of the lack of gastric acid secretion-inhibiting, salivation-inhibiting and mydriatic influences, the novel diazepinones are suitable as vagal pacemakers for the treatment of bradycardias and bradyarrhythmias in human and veterinary medicine.