SPIROCYCLISCHE VERBINDUNGEN UND VERFAHREN ZU DEREN HERSTELLUNG

SPIROCYCLISCHE VERBINDUNGEN UND VERFAHREN ZU DEREN HERSTELLUNG

Mono-Oxa-, thiaspirocyclic-benzene-acetamide and -benzamide compounds of the formula (I) wherein p, n, m, A, E, R, R1, R2, X, Y and Z are as defined in the specification, e.g., (+/-)-(5 alpha ,7 alpha ,9 beta )-3,4-dichloro-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl] benzeneacetamide, an...

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1. Verfasser: JAY KAPLAN,LESTER
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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description Mono-Oxa-, thiaspirocyclic-benzene-acetamide and -benzamide compounds of the formula (I) wherein p, n, m, A, E, R, R1, R2, X, Y and Z are as defined in the specification, e.g., (+/-)-(5 alpha ,7 alpha ,9 beta )-3,4-dichloro-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl] benzeneacetamide, and the pharmacologically acceptable salts thereof, are useful as analgesic compounds having low physical dependence liability, compared to morphine and methodone, and low dysphoria side effects. Some of these compounds have potent analgesic activity when administered orally, and some have low CNS sedative side effects. Pharmaceutical compositions and methods for using these compounds as analgesics are disclosed. Processes for preparing this class of compounds are also disclosed.
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Some of these compounds have potent analgesic activity when administered orally, and some have low CNS sedative side effects. Pharmaceutical compositions and methods for using these compounds as analgesics are disclosed. 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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title SPIROCYCLISCHE VERBINDUNGEN UND VERFAHREN ZU DEREN HERSTELLUNG
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