DE3118360

Prostaglandin analogues of the formula: [wherein R1 represents hydrogen or alkyl of 1 to 12 carbon atoms, R2 represents a single bond or alkylene of from 1 to 5 carbon atoms, R3 represents hydrogen, alkyl or alkoxy of 1 to 8 carbon atoms, cycloalkyl or cycloalkyloxy of 4 to 7 carbon atoms unsubstituted or substituted by alkyl of 1 to 8 carbon atoms, or phenyl or phenoxy unsubstituted or substituted by halogen, trifluoromethyl or alkyl of 1 to 4 carbon atoms, one of R4 and R5 represents hydrogen and the other represents hydroxy or R4 and R5 together represent oxo, R6 represents hydrogen or a hydroxy-protecting group which may be removed under acidic conditions, the double bond between the carbon atoms in positions 13 and 14 is trans, the wavy line attached to the carbon atom in position 15 represents alpha - or beta - configuration or a mixture thereof and, when one of R4 and R5 represents hydrogen and the other represents hydroxy, the configuration of the carbon atom in position 3 is R- or S or a mixture thereof, provided that, when R2 represents a single bond, R3 does not represent alkoxy, cycloalkyloxy or phenoxy and when R6 represents a hydrogen atom, cyclodextrin clathrates thereof and, when R1 represents a hydrogen atom, non-toxic salts thereof, possess selective prostaglandin-like properties.