Bis-aminomethyl-anthraquinone derivs. - with antiprotozoal, antiviral and interferon inducing activity

Bis-aminomethyl-anthraquinone derivs. of formula (I) and their salts with acids are new. R1 and R2 are each H or 1-4C alkyl, or R1 and R2 together form a 4-6C alkylene residue so that N(R1)(R2) is a 5- to 7-membered heterocyclic ring which may contain N, O or S as a further heteroatom and which may...

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Hauptverfasser:	RAETHER,WOLFGANG,DR, WINKELMANN,ERHARDT,DR, ROLLY,HEINRICH,DR
Format:	Patent
Sprache:	eng ; ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	RAETHER,WOLFGANG,DR WINKELMANN,ERHARDT,DR ROLLY,HEINRICH,DR
description	Bis-aminomethyl-anthraquinone derivs. of formula (I) and their salts with acids are new. R1 and R2 are each H or 1-4C alkyl, or R1 and R2 together form a 4-6C alkylene residue so that N(R1)(R2) is a 5- to 7-membered heterocyclic ring which may contain N, O or S as a further heteroatom and which may be substd. by 1-4C alkyl; and R3 is H or OH). The new cpds. can be used for combatting protozoal diseases, in humans and animals, e.g. amoebiasis due to Entamoeba histolytica. In addn., the cpds. have a direct or (due to interferon-induction) indirect activity against influenza and encephalomyocarditis viruses. On account of their interferon-inducing activity, the cpds. can be used against virus and cancer diseases. In addition, the new cpds. (esp. those in which R3 is OH) are effective against trichomoniasis.
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subjects	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	Bis-aminomethyl-anthraquinone derivs. - with antiprotozoal, antiviral and interferon inducing activity
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