NEUE SUBSTITUIERTE 2-PHENYLAMINO-IMIDAZOLINE-(2), DEREN SAEUREADDITIONSSALZE, DIESE ENTHALTENDE ARZNEIMITTEL UND VERFAHREN ZUR HERSTELLUNG DERSELBEN

1. Claims for the Contracting state : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Substituted 2-phenylamino-imidazolines-(2) of general formula (I) see diagramm : EP0030616,P7,F1 wherein R represents an n-propyl, cyclopropylmethyl, cyclopentylmethyl, allyl or methallyl group, and the physiologically acce...

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Hauptverfasser: PICHLER,LUDWIG,DR, KOEPPE,HERBERT,DR, KOBINGER,DR.,WALTER, STAEHLE,HELMUT,DR, LILLIE,CHRISTIAN,DR, GAIDA,WOLFRAM,DR, KUMMER,WERNER,DR, HOEFKE,WOLFGANG,DR
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creator PICHLER,LUDWIG,DR
KOEPPE,HERBERT,DR
KOBINGER,DR.,WALTER
STAEHLE,HELMUT,DR
LILLIE,CHRISTIAN,DR
GAIDA,WOLFRAM,DR
KUMMER,WERNER,DR
HOEFKE,WOLFGANG,DR
description 1. Claims for the Contracting state : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Substituted 2-phenylamino-imidazolines-(2) of general formula (I) see diagramm : EP0030616,P7,F1 wherein R represents an n-propyl, cyclopropylmethyl, cyclopentylmethyl, allyl or methallyl group, and the physiologically acceptable acid addition salts thereof. 1. Claims for the Contracting state : AT Process for preparing substituted 2-phenylamino-imidazolines-(2) of general formula (I) see diagramm : EP0030616,P8,F1 wherein R represents an n-propyl, cyclopropylmethyl, cyclopentylmethyl, allyl or methallyl group, and the physiologically acceptable acid addition salts thereof, characterised in that a) 2-(2,6-dibromo-4-methylphenyl-imino)-imidazolidine of formula II see diagramm : EP0030616,P8,F2 is reacted with a halide of general formula III Hal-R wherein Hal represents a chlorine, bromine or iodine atom and R is as hereinbefore defined, at 40 degrees C to 150 degrees C, or b) a compound of general formula IV see diagramm : EP0030616,P8,F3 wherein R is as hereinbefore defined and A represents a cyano group or the group see diagramm : EP0030616,P8,F4 wherein Y represents an alkoxy or alkylthio group with up to 4 carbon atoms or a mercapto group or an amino group, is reacted with ethylenediamine or the acid addition salts thereof at 60 to 180 degrees C, and the end product obtained according to one of these processes is optionally converted into a corresponding acid addition salt.
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Claims for the Contracting state : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Substituted 2-phenylamino-imidazolines-(2) of general formula (I) see diagramm : EP0030616,P7,F1 wherein R represents an n-propyl, cyclopropylmethyl, cyclopentylmethyl, allyl or methallyl group, and the physiologically acceptable acid addition salts thereof. 1. Claims for the Contracting state : AT Process for preparing substituted 2-phenylamino-imidazolines-(2) of general formula (I) see diagramm : EP0030616,P8,F1 wherein R represents an n-propyl, cyclopropylmethyl, cyclopentylmethyl, allyl or methallyl group, and the physiologically acceptable acid addition salts thereof, characterised in that a) 2-(2,6-dibromo-4-methylphenyl-imino)-imidazolidine of formula II see diagramm : EP0030616,P8,F2 is reacted with a halide of general formula III Hal-R wherein Hal represents a chlorine, bromine or iodine atom and R is as hereinbefore defined, at 40 degrees C to 150 degrees C, or b) a compound of general formula IV see diagramm : EP0030616,P8,F3 wherein R is as hereinbefore defined and A represents a cyano group or the group see diagramm : EP0030616,P8,F4 wherein Y represents an alkoxy or alkylthio group with up to 4 carbon atoms or a mercapto group or an amino group, is reacted with ethylenediamine or the acid addition salts thereof at 60 to 180 degrees C, and the end product obtained according to one of these processes is optionally converted into a corresponding acid addition salt.</description><language>ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1981</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=19810611&amp;DB=EPODOC&amp;CC=DE&amp;NR=2949287A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=19810611&amp;DB=EPODOC&amp;CC=DE&amp;NR=2949287A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PICHLER,LUDWIG,DR</creatorcontrib><creatorcontrib>KOEPPE,HERBERT,DR</creatorcontrib><creatorcontrib>KOBINGER,DR.,WALTER</creatorcontrib><creatorcontrib>STAEHLE,HELMUT,DR</creatorcontrib><creatorcontrib>LILLIE,CHRISTIAN,DR</creatorcontrib><creatorcontrib>GAIDA,WOLFRAM,DR</creatorcontrib><creatorcontrib>KUMMER,WERNER,DR</creatorcontrib><creatorcontrib>HOEFKE,WOLFGANG,DR</creatorcontrib><title>NEUE SUBSTITUIERTE 2-PHENYLAMINO-IMIDAZOLINE-(2), DEREN SAEUREADDITIONSSALZE, DIESE ENTHALTENDE ARZNEIMITTEL UND VERFAHREN ZUR HERSTELLUNG DERSELBEN</title><description>1. Claims for the Contracting state : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Substituted 2-phenylamino-imidazolines-(2) of general formula (I) see diagramm : EP0030616,P7,F1 wherein R represents an n-propyl, cyclopropylmethyl, cyclopentylmethyl, allyl or methallyl group, and the physiologically acceptable acid addition salts thereof. 1. Claims for the Contracting state : AT Process for preparing substituted 2-phenylamino-imidazolines-(2) of general formula (I) see diagramm : EP0030616,P8,F1 wherein R represents an n-propyl, cyclopropylmethyl, cyclopentylmethyl, allyl or methallyl group, and the physiologically acceptable acid addition salts thereof, characterised in that a) 2-(2,6-dibromo-4-methylphenyl-imino)-imidazolidine of formula II see diagramm : EP0030616,P8,F2 is reacted with a halide of general formula III Hal-R wherein Hal represents a chlorine, bromine or iodine atom and R is as hereinbefore defined, at 40 degrees C to 150 degrees C, or b) a compound of general formula IV see diagramm : EP0030616,P8,F3 wherein R is as hereinbefore defined and A represents a cyano group or the group see diagramm : EP0030616,P8,F4 wherein Y represents an alkoxy or alkylthio group with up to 4 carbon atoms or a mercapto group or an amino group, is reacted with ethylenediamine or the acid addition salts thereof at 60 to 180 degrees C, and the end product obtained according to one of these processes is optionally converted into a corresponding acid addition salt.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1981</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNzEFqAkEQheHZZCHGO9QyQmbhKBiXpf20C9oa6a4WnI2IdFYhEcxRPLAjeABXb_E_vkF1U2RQystkYlkQDdTUOw89BN6KtrVsxXHXBlHUH834kxwilBIjR7BzYtJqShw69E2QQFDzHAzqQBw7RW-YIVBWR3vENfsH0eVIHjH1JWTdPOCEsIS-V2_fp59rGT13WNEatvJ1ufwdy_VyOpff8n90aBazRfM158n0hcsdFC9BvA</recordid><startdate>19810611</startdate><enddate>19810611</enddate><creator>PICHLER,LUDWIG,DR</creator><creator>KOEPPE,HERBERT,DR</creator><creator>KOBINGER,DR.,WALTER</creator><creator>STAEHLE,HELMUT,DR</creator><creator>LILLIE,CHRISTIAN,DR</creator><creator>GAIDA,WOLFRAM,DR</creator><creator>KUMMER,WERNER,DR</creator><creator>HOEFKE,WOLFGANG,DR</creator><scope>EVB</scope></search><sort><creationdate>19810611</creationdate><title>NEUE SUBSTITUIERTE 2-PHENYLAMINO-IMIDAZOLINE-(2), DEREN SAEUREADDITIONSSALZE, DIESE ENTHALTENDE ARZNEIMITTEL UND VERFAHREN ZUR HERSTELLUNG DERSELBEN</title><author>PICHLER,LUDWIG,DR ; KOEPPE,HERBERT,DR ; KOBINGER,DR.,WALTER ; STAEHLE,HELMUT,DR ; LILLIE,CHRISTIAN,DR ; GAIDA,WOLFRAM,DR ; KUMMER,WERNER,DR ; HOEFKE,WOLFGANG,DR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_DE2949287A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>ger</language><creationdate>1981</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>PICHLER,LUDWIG,DR</creatorcontrib><creatorcontrib>KOEPPE,HERBERT,DR</creatorcontrib><creatorcontrib>KOBINGER,DR.,WALTER</creatorcontrib><creatorcontrib>STAEHLE,HELMUT,DR</creatorcontrib><creatorcontrib>LILLIE,CHRISTIAN,DR</creatorcontrib><creatorcontrib>GAIDA,WOLFRAM,DR</creatorcontrib><creatorcontrib>KUMMER,WERNER,DR</creatorcontrib><creatorcontrib>HOEFKE,WOLFGANG,DR</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PICHLER,LUDWIG,DR</au><au>KOEPPE,HERBERT,DR</au><au>KOBINGER,DR.,WALTER</au><au>STAEHLE,HELMUT,DR</au><au>LILLIE,CHRISTIAN,DR</au><au>GAIDA,WOLFRAM,DR</au><au>KUMMER,WERNER,DR</au><au>HOEFKE,WOLFGANG,DR</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NEUE SUBSTITUIERTE 2-PHENYLAMINO-IMIDAZOLINE-(2), DEREN SAEUREADDITIONSSALZE, DIESE ENTHALTENDE ARZNEIMITTEL UND VERFAHREN ZUR HERSTELLUNG DERSELBEN</title><date>1981-06-11</date><risdate>1981</risdate><abstract>1. Claims for the Contracting state : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Substituted 2-phenylamino-imidazolines-(2) of general formula (I) see diagramm : EP0030616,P7,F1 wherein R represents an n-propyl, cyclopropylmethyl, cyclopentylmethyl, allyl or methallyl group, and the physiologically acceptable acid addition salts thereof. 1. Claims for the Contracting state : AT Process for preparing substituted 2-phenylamino-imidazolines-(2) of general formula (I) see diagramm : EP0030616,P8,F1 wherein R represents an n-propyl, cyclopropylmethyl, cyclopentylmethyl, allyl or methallyl group, and the physiologically acceptable acid addition salts thereof, characterised in that a) 2-(2,6-dibromo-4-methylphenyl-imino)-imidazolidine of formula II see diagramm : EP0030616,P8,F2 is reacted with a halide of general formula III Hal-R wherein Hal represents a chlorine, bromine or iodine atom and R is as hereinbefore defined, at 40 degrees C to 150 degrees C, or b) a compound of general formula IV see diagramm : EP0030616,P8,F3 wherein R is as hereinbefore defined and A represents a cyano group or the group see diagramm : EP0030616,P8,F4 wherein Y represents an alkoxy or alkylthio group with up to 4 carbon atoms or a mercapto group or an amino group, is reacted with ethylenediamine or the acid addition salts thereof at 60 to 180 degrees C, and the end product obtained according to one of these processes is optionally converted into a corresponding acid addition salt.</abstract><oa>free_for_read</oa></addata></record>
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title NEUE SUBSTITUIERTE 2-PHENYLAMINO-IMIDAZOLINE-(2), DEREN SAEUREADDITIONSSALZE, DIESE ENTHALTENDE ARZNEIMITTEL UND VERFAHREN ZUR HERSTELLUNG DERSELBEN
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