VERFAHREN ZUR HERSTELLUNG VON 3-HYDROXY-6-PHENYL-1,2,3,4-TETRAHYDRO- 1,5-BENZODIAZOCINEN

1. Process for the production of 3-hydroxy-6-phenyl-1,2,3,4-tetrahydro-1,5-benzodiazoci- nes of the general Formula I see diagramm : EP0004024,P13,F1 as well as their acid addition salts, in which R is a hydrogen atom or a methyl group, R1 is a phenyl-, 2-halophenyl or 2-trifluoromethyl-phenyl group...

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Hauptverfasser: ZEUGNER,HORST,.ER.NAT, LIEPMANN,HANS,.ER.NAT, MILKOWSKI,WOLFGANG,.ER.NAT, HUESCHENS,ROLF,.ER.NAT
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creator ZEUGNER,HORST,.ER.NAT
LIEPMANN,HANS,.ER.NAT
MILKOWSKI,WOLFGANG,.ER.NAT
HUESCHENS,ROLF,.ER.NAT
description 1. Process for the production of 3-hydroxy-6-phenyl-1,2,3,4-tetrahydro-1,5-benzodiazoci- nes of the general Formula I see diagramm : EP0004024,P13,F1 as well as their acid addition salts, in which R is a hydrogen atom or a methyl group, R1 is a phenyl-, 2-halophenyl or 2-trifluoromethyl-phenyl group and R2 is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, characterized in that 2-aminobenzophenones of the general Formula II see diagramm : EP0004024,P13,F2 in which R, R1 and R2 have the meanings defined above, or their acid addition salts are cyclised at elevated temperature in the presence of an inert organic solvent.
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Process for the production of 3-hydroxy-6-phenyl-1,2,3,4-tetrahydro-1,5-benzodiazoci- nes of the general Formula I see diagramm : EP0004024,P13,F1 as well as their acid addition salts, in which R is a hydrogen atom or a methyl group, R1 is a phenyl-, 2-halophenyl or 2-trifluoromethyl-phenyl group and R2 is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, characterized in that 2-aminobenzophenones of the general Formula II see diagramm : EP0004024,P13,F2 in which R, R1 and R2 have the meanings defined above, or their acid addition salts are cyclised at elevated temperature in the presence of an inert organic solvent.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1979</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyjEKwjAUgOEsDqLeIQfIA9NU0TG2r6YQXiSmpelSisRJtFDvjyAewOkfvn_JuhZ9pY1H4n3juUF_DWhtQ2feOuIKTCy96yLs4WKQogUpMqFEDgGD118FLsUOTki9K2vdu6ImpDVb3MfHnDa_rhivMBQG0vQa0jyNt_RM76HE7CC3Kj9qqf5YPliaMDo</recordid><startdate>19790920</startdate><enddate>19790920</enddate><creator>ZEUGNER,HORST,.ER.NAT</creator><creator>LIEPMANN,HANS,.ER.NAT</creator><creator>MILKOWSKI,WOLFGANG,.ER.NAT</creator><creator>HUESCHENS,ROLF,.ER.NAT</creator><scope>EVB</scope></search><sort><creationdate>19790920</creationdate><title>VERFAHREN ZUR HERSTELLUNG VON 3-HYDROXY-6-PHENYL-1,2,3,4-TETRAHYDRO- 1,5-BENZODIAZOCINEN</title><author>ZEUGNER,HORST,.ER.NAT ; LIEPMANN,HANS,.ER.NAT ; MILKOWSKI,WOLFGANG,.ER.NAT ; HUESCHENS,ROLF,.ER.NAT</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_DE2810349A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>ger</language><creationdate>1979</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ZEUGNER,HORST,.ER.NAT</creatorcontrib><creatorcontrib>LIEPMANN,HANS,.ER.NAT</creatorcontrib><creatorcontrib>MILKOWSKI,WOLFGANG,.ER.NAT</creatorcontrib><creatorcontrib>HUESCHENS,ROLF,.ER.NAT</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZEUGNER,HORST,.ER.NAT</au><au>LIEPMANN,HANS,.ER.NAT</au><au>MILKOWSKI,WOLFGANG,.ER.NAT</au><au>HUESCHENS,ROLF,.ER.NAT</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>VERFAHREN ZUR HERSTELLUNG VON 3-HYDROXY-6-PHENYL-1,2,3,4-TETRAHYDRO- 1,5-BENZODIAZOCINEN</title><date>1979-09-20</date><risdate>1979</risdate><abstract>1. 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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title VERFAHREN ZUR HERSTELLUNG VON 3-HYDROXY-6-PHENYL-1,2,3,4-TETRAHYDRO- 1,5-BENZODIAZOCINEN
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