VERFAHREN ZUR REINIGUNG VON ROHER CHENODESOXYCHOLSAEURE
A process for preparing a form of chenodeoxycholic acid having a melting point of ca. 166 DEG C from the amorphous form of the acid or from the form melting at ca. 120 DEG C. The amorphous or low melting forms of chenodeoxycholic acid, in a suspension in water, are seeded with preprepared crystallin...
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| creator | FABIAN,FRITZ ARTHUR JONES,WILLIAM FRANCIS FROST,HENRY JAMES SHARPE,CHRISTOPHER |
| description | A process for preparing a form of chenodeoxycholic acid having a melting point of ca. 166 DEG C from the amorphous form of the acid or from the form melting at ca. 120 DEG C. The amorphous or low melting forms of chenodeoxycholic acid, in a suspension in water, are seeded with preprepared crystalline acid of the high melting form and the acid product treated, in suspension, at a temperature of not greater than 85 DEG C to complete the conversion of the chenodeoxycholic acid to the high melting form. Crude chenodeoxycholic acid of the low melting form is purified by a process which involves forming a mixture of the crude acid, methanol, a base and a calcium or strontium salt, separating the precipitated crystalline calcium or strontium chenodeoxycholanate, dissolving the salt in a solution of acetic or propionic acid, diluting the solution with water to precipitate the free acid in purified form and recovering the purified acid. |
| format | Patent |
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The amorphous or low melting forms of chenodeoxycholic acid, in a suspension in water, are seeded with preprepared crystalline acid of the high melting form and the acid product treated, in suspension, at a temperature of not greater than 85 DEG C to complete the conversion of the chenodeoxycholic acid to the high melting form. Crude chenodeoxycholic acid of the low melting form is purified by a process which involves forming a mixture of the crude acid, methanol, a base and a calcium or strontium salt, separating the precipitated crystalline calcium or strontium chenodeoxycholanate, dissolving the salt in a solution of acetic or propionic acid, diluting the solution with water to precipitate the free acid in purified form and recovering the purified acid.</description><edition>2</edition><language>ger</language><subject>CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY ; STEROIDS</subject><creationdate>1976</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19760701&DB=EPODOC&CC=DE&NR=2557287A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19760701&DB=EPODOC&CC=DE&NR=2557287A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FABIAN,FRITZ</creatorcontrib><creatorcontrib>ARTHUR JONES,WILLIAM</creatorcontrib><creatorcontrib>FRANCIS FROST,HENRY</creatorcontrib><creatorcontrib>JAMES SHARPE,CHRISTOPHER</creatorcontrib><title>VERFAHREN ZUR REINIGUNG VON ROHER CHENODESOXYCHOLSAEURE</title><description>A process for preparing a form of chenodeoxycholic acid having a melting point of ca. 166 DEG C from the amorphous form of the acid or from the form melting at ca. 120 DEG C. The amorphous or low melting forms of chenodeoxycholic acid, in a suspension in water, are seeded with preprepared crystalline acid of the high melting form and the acid product treated, in suspension, at a temperature of not greater than 85 DEG C to complete the conversion of the chenodeoxycholic acid to the high melting form. Crude chenodeoxycholic acid of the low melting form is purified by a process which involves forming a mixture of the crude acid, methanol, a base and a calcium or strontium salt, separating the precipitated crystalline calcium or strontium chenodeoxycholanate, dissolving the salt in a solution of acetic or propionic acid, diluting the solution with water to precipitate the free acid in purified form and recovering the purified acid.</description><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>STEROIDS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1976</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAPcw1yc_QIcvVTiAoNUghy9fTzdA_1c1cI8_dTCPL3cA1ScPZw9fN3cQ32j4h09vD3CXZ0DQ1y5WFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8S6uRqam5kYW5o6GxkQoAQAjQyhH</recordid><startdate>19760701</startdate><enddate>19760701</enddate><creator>FABIAN,FRITZ</creator><creator>ARTHUR JONES,WILLIAM</creator><creator>FRANCIS FROST,HENRY</creator><creator>JAMES SHARPE,CHRISTOPHER</creator><scope>EVB</scope></search><sort><creationdate>19760701</creationdate><title>VERFAHREN ZUR REINIGUNG VON ROHER CHENODESOXYCHOLSAEURE</title><author>FABIAN,FRITZ ; ARTHUR JONES,WILLIAM ; FRANCIS FROST,HENRY ; JAMES SHARPE,CHRISTOPHER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_DE2557287A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>ger</language><creationdate>1976</creationdate><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>STEROIDS</topic><toplevel>online_resources</toplevel><creatorcontrib>FABIAN,FRITZ</creatorcontrib><creatorcontrib>ARTHUR JONES,WILLIAM</creatorcontrib><creatorcontrib>FRANCIS FROST,HENRY</creatorcontrib><creatorcontrib>JAMES SHARPE,CHRISTOPHER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>FABIAN,FRITZ</au><au>ARTHUR JONES,WILLIAM</au><au>FRANCIS FROST,HENRY</au><au>JAMES SHARPE,CHRISTOPHER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>VERFAHREN ZUR REINIGUNG VON ROHER CHENODESOXYCHOLSAEURE</title><date>1976-07-01</date><risdate>1976</risdate><abstract>A process for preparing a form of chenodeoxycholic acid having a melting point of ca. 166 DEG C from the amorphous form of the acid or from the form melting at ca. 120 DEG C. The amorphous or low melting forms of chenodeoxycholic acid, in a suspension in water, are seeded with preprepared crystalline acid of the high melting form and the acid product treated, in suspension, at a temperature of not greater than 85 DEG C to complete the conversion of the chenodeoxycholic acid to the high melting form. Crude chenodeoxycholic acid of the low melting form is purified by a process which involves forming a mixture of the crude acid, methanol, a base and a calcium or strontium salt, separating the precipitated crystalline calcium or strontium chenodeoxycholanate, dissolving the salt in a solution of acetic or propionic acid, diluting the solution with water to precipitate the free acid in purified form and recovering the purified acid.</abstract><edition>2</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY METALLURGY ORGANIC CHEMISTRY STEROIDS |
| title | VERFAHREN ZUR REINIGUNG VON ROHER CHENODESOXYCHOLSAEURE |
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