Testosterone and analogues prepn. - by reducing 3,17-diketo-4-androstenes with diisobutyl-aluminium hydride
17 beta-Hydroxy-4-androsten-3-ones of formula (I): (where R1 and R2 are H or Me) are prepd. by reducing the corresp. 3,17-diketo-4-androstenes (II) with diisobutylaluminium hydride (III) and an aliphatic or cycloaliphatic ketone (IV) in an inert solvent, opt. contg. an added alcohol, at -25 to +35 d...
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| creator | EDER,ULRICH,DR |
| description | 17 beta-Hydroxy-4-androsten-3-ones of formula (I): (where R1 and R2 are H or Me) are prepd. by reducing the corresp. 3,17-diketo-4-androstenes (II) with diisobutylaluminium hydride (III) and an aliphatic or cycloaliphatic ketone (IV) in an inert solvent, opt. contg. an added alcohol, at -25 to +35 degrees C (pref. -10 to +10 degrees C). Cpds. (I) are medicaments (e.g. testosterone) or intermediates therefore. The process gives high yields (e.g. 70-87%). |
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Cpds. (I) are medicaments (e.g. testosterone) or intermediates therefore. 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Cpds. (I) are medicaments (e.g. testosterone) or intermediates therefore. 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Cpds. (I) are medicaments (e.g. testosterone) or intermediates therefore. The process gives high yields (e.g. 70-87%).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY METALLURGY ORGANIC CHEMISTRY STEROIDS |
| title | Testosterone and analogues prepn. - by reducing 3,17-diketo-4-androstenes with diisobutyl-aluminium hydride |
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