DE2023450

1,265,444. 1,2 - Methylene - 20 - spiroxanes. MERCK & CO. Inc. 11 May, 1970 [14 May, 1969; 19 March, 1970], No. 22583/70. Heading C2U. Novel steroids of the formulµ (where each X is Cl or F, R1 is H or CH 3 , R is -CH 2 - or -CO- and Z is oxo, or α- or #- hydroxy or -acyloxy) are prepared as fol...

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Hauptverfasser:	RASMUSSON, GARY HENRY, WATCHUNG, ARTH, GLEN EDWARD, CRANFORD
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS
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creator	RASMUSSON, GARY HENRY, WATCHUNG ARTH, GLEN EDWARD, CRANFORD
description	1,265,444. 1,2 - Methylene - 20 - spiroxanes. MERCK & CO. Inc. 11 May, 1970 [14 May, 1969; 19 March, 1970], No. 22583/70. Heading C2U. Novel steroids of the formulµ (where each X is Cl or F, R1 is H or CH 3 , R is -CH 2 - or -CO- and Z is oxo, or α- or #- hydroxy or -acyloxy) are prepared as follows 3-Ols are prepared by reduction of the 3-ones; they may subsequently be acylated. The conversion of compounds (E) to compound (IIIa) is effected via the 6,7-epoxides and the 1α- halomethyl - 6 - halo - 20 - spiroxa - 4,6 - dien- 3-ones; compounds (T) are similarly converted to compounds (V). The novel steroids are stated to be androgen antagonists, of use in the treatment of hyperandrogenic disorders. They may be made up into pharmaceutical compositions with suitable carriers.
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Novel steroids of the formulµ (where each X is Cl or F, R1 is H or CH 3 , R is -CH 2 - or -CO- and Z is oxo, or α- or #- hydroxy or -acyloxy) are prepared as follows 3-Ols are prepared by reduction of the 3-ones; they may subsequently be acylated. The conversion of compounds (E) to compound (IIIa) is effected via the 6,7-epoxides and the 1α- halomethyl - 6 - halo - 20 - spiroxa - 4,6 - dien- 3-ones; compounds (T) are similarly converted to compounds (V). The novel steroids are stated to be androgen antagonists, of use in the treatment of hyperandrogenic disorders. 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MERCK & CO. Inc. 11 May, 1970 [14 May, 1969; 19 March, 1970], No. 22583/70. Heading C2U. Novel steroids of the formulµ (where each X is Cl or F, R1 is H or CH 3 , R is -CH 2 - or -CO- and Z is oxo, or α- or #- hydroxy or -acyloxy) are prepared as follows 3-Ols are prepared by reduction of the 3-ones; they may subsequently be acylated. The conversion of compounds (E) to compound (IIIa) is effected via the 6,7-epoxides and the 1α- halomethyl - 6 - halo - 20 - spiroxa - 4,6 - dien- 3-ones; compounds (T) are similarly converted to compounds (V). The novel steroids are stated to be androgen antagonists, of use in the treatment of hyperandrogenic disorders. They may be made up into pharmaceutical compositions with suitable carriers.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>STEROIDS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1979</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZOB0cTUyMDI2MTXgYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxcPXOxsZEKAEAxsQaUQ</recordid><startdate>19790531</startdate><enddate>19790531</enddate><creator>RASMUSSON, GARY HENRY, WATCHUNG</creator><creator>ARTH, GLEN EDWARD, CRANFORD</creator><scope>EVB</scope></search><sort><creationdate>19790531</creationdate><title>DE2023450</title><author>RASMUSSON, GARY HENRY, WATCHUNG ; ARTH, GLEN EDWARD, CRANFORD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_DE2023450C33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1979</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>STEROIDS</topic><toplevel>online_resources</toplevel><creatorcontrib>RASMUSSON, GARY HENRY, WATCHUNG</creatorcontrib><creatorcontrib>ARTH, GLEN EDWARD, CRANFORD</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RASMUSSON, GARY HENRY, WATCHUNG</au><au>ARTH, GLEN EDWARD, CRANFORD</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>DE2023450</title><date>1979-05-31</date><risdate>1979</risdate><abstract>1,265,444. 1,2 - Methylene - 20 - spiroxanes. MERCK & CO. Inc. 11 May, 1970 [14 May, 1969; 19 March, 1970], No. 22583/70. Heading C2U. Novel steroids of the formulµ (where each X is Cl or F, R1 is H or CH 3 , R is -CH 2 - or -CO- and Z is oxo, or α- or #- hydroxy or -acyloxy) are prepared as follows 3-Ols are prepared by reduction of the 3-ones; they may subsequently be acylated. The conversion of compounds (E) to compound (IIIa) is effected via the 6,7-epoxides and the 1α- halomethyl - 6 - halo - 20 - spiroxa - 4,6 - dien- 3-ones; compounds (T) are similarly converted to compounds (V). The novel steroids are stated to be androgen antagonists, of use in the treatment of hyperandrogenic disorders. They may be made up into pharmaceutical compositions with suitable carriers.</abstract><edition>2</edition><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS
title	DE2023450
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