Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel

Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel

The present invention relates to bicyclene of general formula (I) substituted by an aminocarbonyl radical, wherein R1-R6, X1-X3, Y1-Y2 are defined as in claim 1 and the tautomers, stereoisomers, mixtures and salts thereof have valuable properties. The compounds of general formula (I), wherein X3 is...

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Hauptverfasser: WIENEN, WOLFGANG-BIOL. DR., 88400 BIBERACH, DE, LEHMANN-LINTZ, THORSTEN. DR., 88416 OCHSENHAUSEN, DE, HECKEL, ARMIN. DR., 88400 BIBERACH, DE, STASSEN, JEAN MARIE. DR., 88447 WARTHAUSEN, DE, SOYKA, RAINER. DR., 88400 BIBERACH, DE, WALTER, RAINER. DR., 88400 BIBERACH, DE
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator WIENEN, WOLFGANG-BIOL. DR., 88400 BIBERACH, DE
LEHMANN-LINTZ, THORSTEN. DR., 88416 OCHSENHAUSEN, DE
HECKEL, ARMIN. DR., 88400 BIBERACH, DE
STASSEN, JEAN MARIE. DR., 88447 WARTHAUSEN, DE
SOYKA, RAINER. DR., 88400 BIBERACH, DE
WALTER, RAINER. DR., 88400 BIBERACH, DE
description The present invention relates to bicyclene of general formula (I) substituted by an aminocarbonyl radical, wherein R1-R6, X1-X3, Y1-Y2 are defined as in claim 1 and the tautomers, stereoisomers, mixtures and salts thereof have valuable properties. The compounds of general formula (I), wherein X3 is a cyano group, represent valuable intermediate products in the production of the other compounds in general formula (I). The compounds of general formula (I), wherein X3 is an amino, 2-amino-1H-imidazolyl or RaNH-C(C=NH) group, and the tautomers and stereoisomers thereof have valuable pharmacological properties, especially an antithrombotic effect which is based on a thrombin inhibiting effect.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
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