Verfahren zur Herstellung von Phenylacetylhydroxamsaeuren

Novel compounds of formula wherein R represents C3- 8 alkyl, cycloalkyl, C4- 8 alkoxy, cycloalkyloxy, cycloalkylalkyloxy, alkenyloxy, alkylthio, cycloakylthio, arylalkyloxy, or arylalkylthio, R1 represents one or two radicals of the same kind as R being the same or different, or hydrogen, and R11 and R111 each represent hydrogen or an alkyl radical, may be prepared (1) when R11 and R111 are hydrogen, by reacting an acid chloride with ammonia, or by heating an ester of the acid with an alcoholic solution of ammonia gas or by reacting an ester of the acid with concentrated ammonia, and (2) when R11 and R111 are each alkyl or one thereof is hydrogen and the other is alkyl, by reacting an acid chloride with an amine R11R111NH. The acid amides may be obtained by converting the corresponding acid to its acid chloride using thionyl chloride or phosphorus pentachloride, and reacting the acid chloride with ammonia. They may also be obtained by reacting a suitable acid with ammonium carbonate in the presence of acetic acid or by the Willgerodt reaction starting from a a suitable substituted acetophenone. Therapeutic compositions having an antalgic, antipyretic, antiphlogistic, tranquillizing and hypocholesterolemic activity contain as active ingredient a compound of the formula given above.