Testing of potential pharmaceutically active substances for suitability as antiviral comprises forming an assay, which acts against treatment-evasive potential of a mutable virus by inclusion of all currently available same virus type

Procedure for the testing of potential pharmaceutically active substances for the suitability as antiviral comprises forming an assay, which: acts against the treatment-evasive potential of a mutable virus by means of inclusion of all the currently available types in the form of a representative sel...

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Hauptverfasser: THUERK, MARCEL, EGOROV, MARK, WIESENFELDT, MARTIN, GOETZ, RUEDIGER
Format: Patent
Sprache:eng ; ger
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Zusammenfassung:Procedure for the testing of potential pharmaceutically active substances for the suitability as antiviral comprises forming an assay, which: acts against the treatment-evasive potential of a mutable virus by means of inclusion of all the currently available types in the form of a representative selection of a sub-type of the same virus type, and hence compensates the risk of mutation; clears off the distinctiveness between the virus-targeted and a host cell-based testing of the drug; and considers the virus including the host cell as a single entity. Verfahren zur Testung von potentiellen pharmazeutisch aktiven Substanzen zur Eignung als Virustatika durch Etablierung eines Assays, das die Möglichkeiten eines Virus, der Behandlung durch Mutation zu entweichen, durch Einbeziehung aller gegenwärtig verfügbaren Virustypen des gleichen Typs entgegenwirkt und damit kompensiert.