Composition containing 4-piperazino-benzoylguanidine derivative, useful e.g. for treating cardiac infarction, containing component to improve local tolerance, e.g. beta-cyclodextrin derivative or polymer
Pharmaceutical compositions (A) containing 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-benzoylguanidine (I) (or its acid addition salt, specifically the hydrochloride) are claimed, where (A) additionally contains a substituted beta -cyclodextrin (II), (I) is encapsulated in a polymer...
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| creator | KRUSS, BERND VOTTELER, CHRISTINE |
| description | Pharmaceutical compositions (A) containing 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-benzoylguanidine (I) (or its acid addition salt, specifically the hydrochloride) are claimed, where (A) additionally contains a substituted beta -cyclodextrin (II), (I) is encapsulated in a polymer (III) or (I) is incorporated in mixed micelles (IV) consisting of a phospholipid and a bile acid salt, are new. Independent claims are also included for the use of (II), (III) or (IV) for the preparation of (A).
Die Erfindung betrifft neue Formulierungen zur Verbesserung der lokalen Verträglichkeit von intravenös verabreichtem 4-(4-(2-Pyrrolylcarbonyl)-1-piperazinyl)-3-trifluormethyl-benzoylguanidin Hydrochlorid. |
| format | Patent |
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Die Erfindung betrifft neue Formulierungen zur Verbesserung der lokalen Verträglichkeit von intravenös verabreichtem 4-(4-(2-Pyrrolylcarbonyl)-1-piperazinyl)-3-trifluormethyl-benzoylguanidin Hydrochlorid.</description><edition>7</edition><language>eng ; ger</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030327&DB=EPODOC&CC=DE&NR=10144030A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030327&DB=EPODOC&CC=DE&NR=10144030A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KRUSS, BERND</creatorcontrib><creatorcontrib>VOTTELER, CHRISTINE</creatorcontrib><title>Composition containing 4-piperazino-benzoylguanidine derivative, useful e.g. for treating cardiac infarction, containing component to improve local tolerance, e.g. beta-cyclodextrin derivative or polymer</title><description>Pharmaceutical compositions (A) containing 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-benzoylguanidine (I) (or its acid addition salt, specifically the hydrochloride) are claimed, where (A) additionally contains a substituted beta -cyclodextrin (II), (I) is encapsulated in a polymer (III) or (I) is incorporated in mixed micelles (IV) consisting of a phospholipid and a bile acid salt, are new. Independent claims are also included for the use of (II), (III) or (IV) for the preparation of (A).
Die Erfindung betrifft neue Formulierungen zur Verbesserung der lokalen Verträglichkeit von intravenös verabreichtem 4-(4-(2-Pyrrolylcarbonyl)-1-piperazinyl)-3-trifluormethyl-benzoylguanidin Hydrochlorid.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2003</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjk1qw0AMhb3poqS9g7KPg018gZAfeoDsgyLLRjCWBnls6lwxl-qkdJFlV4L3Ht-n9-JxsCHaKElMgUwTior20JRRIjveRa28sd5tCf2EKq0oQ8suMyaZeQPTyN0UgLf9FjpzSM65yQhCbwUJRDt0ego2rwZ6ipU1QTKQIbrNDMEIQw5CVitl-i_2xglLWihYy9_JRV8egKyMFpaB_aN46zCM_Pl3V8X6fLocvkqOduUxIrFyuh5PdVU3TbWr9vXuP5sfNZ5mHQ</recordid><startdate>20030327</startdate><enddate>20030327</enddate><creator>KRUSS, BERND</creator><creator>VOTTELER, CHRISTINE</creator><scope>EVB</scope></search><sort><creationdate>20030327</creationdate><title>Composition containing 4-piperazino-benzoylguanidine derivative, useful e.g. for treating cardiac infarction, containing component to improve local tolerance, e.g. beta-cyclodextrin derivative or polymer</title><author>KRUSS, BERND ; VOTTELER, CHRISTINE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_DE10144030A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; ger</language><creationdate>2003</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>KRUSS, BERND</creatorcontrib><creatorcontrib>VOTTELER, CHRISTINE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KRUSS, BERND</au><au>VOTTELER, CHRISTINE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Composition containing 4-piperazino-benzoylguanidine derivative, useful e.g. for treating cardiac infarction, containing component to improve local tolerance, e.g. beta-cyclodextrin derivative or polymer</title><date>2003-03-27</date><risdate>2003</risdate><abstract>Pharmaceutical compositions (A) containing 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-benzoylguanidine (I) (or its acid addition salt, specifically the hydrochloride) are claimed, where (A) additionally contains a substituted beta -cyclodextrin (II), (I) is encapsulated in a polymer (III) or (I) is incorporated in mixed micelles (IV) consisting of a phospholipid and a bile acid salt, are new. Independent claims are also included for the use of (II), (III) or (IV) for the preparation of (A).
Die Erfindung betrifft neue Formulierungen zur Verbesserung der lokalen Verträglichkeit von intravenös verabreichtem 4-(4-(2-Pyrrolylcarbonyl)-1-piperazinyl)-3-trifluormethyl-benzoylguanidin Hydrochlorid.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Composition containing 4-piperazino-benzoylguanidine derivative, useful e.g. for treating cardiac infarction, containing component to improve local tolerance, e.g. beta-cyclodextrin derivative or polymer |
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