Composition containing 4-piperazino-benzoylguanidine derivative, useful e.g. for treating cardiac infarction, containing component to improve local tolerance, e.g. beta-cyclodextrin derivative or polymer

Pharmaceutical compositions (A) containing 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-benzoylguanidine (I) (or its acid addition salt, specifically the hydrochloride) are claimed, where (A) additionally contains a substituted beta -cyclodextrin (II), (I) is encapsulated in a polymer (III) or (I) is incorporated in mixed micelles (IV) consisting of a phospholipid and a bile acid salt, are new. Independent claims are also included for the use of (II), (III) or (IV) for the preparation of (A). Die Erfindung betrifft neue Formulierungen zur Verbesserung der lokalen Verträglichkeit von intravenös verabreichtem 4-(4-(2-Pyrrolylcarbonyl)-1-piperazinyl)-3-trifluormethyl-benzoylguanidin Hydrochlorid.