Preparation of 4-methylacetophenone, used as intermediate in synthesis of agrochemicals and pharmaceuticals, by reacting p-tolyl-magnesium halide in ether and acetic anhydride at a set temperature

Preparation of 4-methylacetophenone, used as intermediate in synthesis of agrochemicals and pharmaceuticals, by reacting p-tolyl-magnesium halide in ether and acetic anhydride at a set temperature

Preparation of isomer-pure 4-methylacetophenone (I) comprises reacting p-tolyl-magnesium halide (II) in suitable ethers with acetic anhydride (III) at -40 to +10 deg C, then working the reaction solution up in a suitable way and separating (I). Verfahren zur Herstellung von isomerenreinem 4-Methylac...

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Hauptverfasser: SCHERER, STEFAN, TETZLAFF, HERRIBERT, MEUDT, ANDREAS, VOLLMUELLER, FRANK, KAUTZ, HEINZ GEORG
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
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TETZLAFF, HERRIBERT
MEUDT, ANDREAS
VOLLMUELLER, FRANK
KAUTZ, HEINZ GEORG
description Preparation of isomer-pure 4-methylacetophenone (I) comprises reacting p-tolyl-magnesium halide (II) in suitable ethers with acetic anhydride (III) at -40 to +10 deg C, then working the reaction solution up in a suitable way and separating (I). Verfahren zur Herstellung von isomerenreinem 4-Methylacetophenon der Formel (I), DOLLAR F1 durch Umsetzung von p-Tolylmagnesiumhalogenid in geeigneten Ethern mit Essigsäureanhydrid bei einer Temperatur im Bereich von -40 DEG C bis +10 DEG C, anschließender geeigneter Aufarbeitung der Reaktionslösung und Abtrennung des 4-Methylacetophenons. DOLLAR A Die Konzentration der eingesetzten Grignardlösung liegt vorzugsweise im Bereich von 5 bis 40 Gew.-%.
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CHEMISTRY
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title Preparation of 4-methylacetophenone, used as intermediate in synthesis of agrochemicals and pharmaceuticals, by reacting p-tolyl-magnesium halide in ether and acetic anhydride at a set temperature
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