VERFAHREN ZUR HERSTELLUNG VON (1,2)-ANELLIERTEN 1,4-BENZODIAZEPIN-VERBINDUNGEN

[1,2]-fused 1,4-benzodiazepine compounds are disclosed corresponding to the general formula I I wherein X is an oxygen or sulfur atom or an optionally substituted imino group, R1 is a hydrogen or halogen atom, lower alkyl radical, a lower alkoxy radical or a nitro group and R2 is a hydrogen or halog...

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Hauptverfasser: ZEUGNER,HORST, BENSON,WERNER, MUESCH,HERBERT, RUHLAND,MICHAEL, LIEPMANN,HANS, HEINEMANN,HENNIG
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creator ZEUGNER,HORST
BENSON,WERNER
MUESCH,HERBERT
RUHLAND,MICHAEL
LIEPMANN,HANS
HEINEMANN,HENNIG
description [1,2]-fused 1,4-benzodiazepine compounds are disclosed corresponding to the general formula I I wherein X is an oxygen or sulfur atom or an optionally substituted imino group, R1 is a hydrogen or halogen atom, lower alkyl radical, a lower alkoxy radical or a nitro group and R2 is a hydrogen or halogen atom, a lower alkyl radical, a lower alkoxy radical or a nitro group, or if R1 is a hydrogen atom, R2 may also be a lower alkylthio radical, or, if R1 is a hydrogen atom and X is a sulfur atom or an imino group, R2 may be a trifluoromethyl radical; or R1 and R2 are bonded to adjacent carbon atoms and together denote a methylenedioxy or ethylenedioxy radical; R3 is an optionally substituted furyl, thienyl, pyrrolyl or pyridyl radical and n is zero or, if R3 is furyl or thienyl, n may be 0 or 1. The compounds may be in the form of their optical isomers or acid addition salts. The compounds exhibit neuroleptic properties. Processes for preparing the compounds and pharmaceutical compositions containing them are also disclosed.
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The compounds may be in the form of their optical isomers or acid addition salts. The compounds exhibit neuroleptic properties. 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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title VERFAHREN ZUR HERSTELLUNG VON (1,2)-ANELLIERTEN 1,4-BENZODIAZEPIN-VERBINDUNGEN
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