Process for preparing 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine monohydrate
Zpusob prípravy 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu monohydrátu vzorce I reakcí 2-(4-methoxykarbonylpyrazol-1-yl)adenosinu vzorce III s roztokem methylaminu v nevodném rozpoustedle poprípade v kombinaci s dalsím inertním rozpoustedlem za vzniku bezvodého 2-[4-[(methylamino)karbon...
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| creator | DVORAKOVA BARBORA KVAPIL LUBOMIR HRADIL PAVEL GREPL MARTIN SLUZAR PETR |
| description | Zpusob prípravy 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu monohydrátu vzorce I reakcí 2-(4-methoxykarbonylpyrazol-1-yl)adenosinu vzorce III s roztokem methylaminu v nevodném rozpoustedle poprípade v kombinaci s dalsím inertním rozpoustedlem za vzniku bezvodého 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu, který se pridáním vody privede na 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosin monohydrát vzorce I.
In the present invention, there is disclosed a process for preparing 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine monohydrate of the general formula I by reacting 2-(4-methoxycarbonyl pyrazol-1-yl)adenosine of the general formula III with a methylamine solution in a nonaqueous solvent optionally in combination with another inert solvent to obtain anhydrous 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine, which is then converted by the addition of water to 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine monohydrate of the general formula I. |
| format | Patent |
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In the present invention, there is disclosed a process for preparing 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine monohydrate of the general formula I by reacting 2-(4-methoxycarbonyl pyrazol-1-yl)adenosine of the general formula III with a methylamine solution in a nonaqueous solvent optionally in combination with another inert solvent to obtain anhydrous 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine, which is then converted by the addition of water to 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine monohydrate of the general formula I.</description><language>cze ; eng</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; SUGARS</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130904&DB=EPODOC&CC=CZ&NR=304053B6$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130904&DB=EPODOC&CC=CZ&NR=304053B6$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DVORAKOVA BARBORA</creatorcontrib><creatorcontrib>KVAPIL LUBOMIR</creatorcontrib><creatorcontrib>HRADIL PAVEL</creatorcontrib><creatorcontrib>GREPL MARTIN</creatorcontrib><creatorcontrib>SLUZAR PETR</creatorcontrib><title>Process for preparing 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine monohydrate</title><description>Zpusob prípravy 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu monohydrátu vzorce I reakcí 2-(4-methoxykarbonylpyrazol-1-yl)adenosinu vzorce III s roztokem methylaminu v nevodném rozpoustedle poprípade v kombinaci s dalsím inertním rozpoustedlem za vzniku bezvodého 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu, který se pridáním vody privede na 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosin monohydrát vzorce I.
In the present invention, there is disclosed a process for preparing 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine monohydrate of the general formula I by reacting 2-(4-methoxycarbonyl pyrazol-1-yl)adenosine of the general formula III with a methylamine solution in a nonaqueous solvent optionally in combination with another inert solvent to obtain anhydrous 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine, which is then converted by the addition of water to 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine monohydrate of the general formula I.</description><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2013</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFirEKwjAQQLs4iPoNZtQhUG31AyxKRwcXLVLO9GoLyV24ZIlfbwd3p_d4vHl2vwobDEH1LMoLepCR3mqvm1I3G4dxSBbcSLw1IC-mZJ96p2vtk8CH7eRTgQ6Jw0ioHBMPqROIuMxmPdiAqx8X2fpyvlW1Rs8tBg8GCWNbPYq8zA_F6Vj8P76c-zlR</recordid><startdate>20130904</startdate><enddate>20130904</enddate><creator>DVORAKOVA BARBORA</creator><creator>KVAPIL LUBOMIR</creator><creator>HRADIL PAVEL</creator><creator>GREPL MARTIN</creator><creator>SLUZAR PETR</creator><scope>EVB</scope></search><sort><creationdate>20130904</creationdate><title>Process for preparing 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine monohydrate</title><author>DVORAKOVA BARBORA ; KVAPIL LUBOMIR ; HRADIL PAVEL ; GREPL MARTIN ; SLUZAR PETR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CZ304053B63</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>cze ; eng</language><creationdate>2013</creationdate><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>DVORAKOVA BARBORA</creatorcontrib><creatorcontrib>KVAPIL LUBOMIR</creatorcontrib><creatorcontrib>HRADIL PAVEL</creatorcontrib><creatorcontrib>GREPL MARTIN</creatorcontrib><creatorcontrib>SLUZAR PETR</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DVORAKOVA BARBORA</au><au>KVAPIL LUBOMIR</au><au>HRADIL PAVEL</au><au>GREPL MARTIN</au><au>SLUZAR PETR</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Process for preparing 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine monohydrate</title><date>2013-09-04</date><risdate>2013</risdate><abstract>Zpusob prípravy 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu monohydrátu vzorce I reakcí 2-(4-methoxykarbonylpyrazol-1-yl)adenosinu vzorce III s roztokem methylaminu v nevodném rozpoustedle poprípade v kombinaci s dalsím inertním rozpoustedlem za vzniku bezvodého 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu, který se pridáním vody privede na 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosin monohydrát vzorce I.
In the present invention, there is disclosed a process for preparing 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine monohydrate of the general formula I by reacting 2-(4-methoxycarbonyl pyrazol-1-yl)adenosine of the general formula III with a methylamine solution in a nonaqueous solvent optionally in combination with another inert solvent to obtain anhydrous 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine, which is then converted by the addition of water to 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine monohydrate of the general formula I.</abstract><oa>free_for_read</oa></addata></record> |
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| title | Process for preparing 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine monohydrate |
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