OXAZOLIDINONE DERIVATIVE, PROCESS OF ITS PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF
Novel oxazolidinone derivatives of the formula I wherein R is a phenyl radical which is unsubstituted or substituted once by CN, H2N-CH2-, A2N-CH2-, H2N-C(=NH)-, H2N-C(=NH)-NH-, H2N-C(=NH)-NH-CH2-, HO-NH-C(=NH)- or HO-NH-C(=NH)-NH-, X is O, S, SO, SO2, -NH- or -NA-, B is A is alkyl having 1 to 6 C a...
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| creator | JURASZYK HORST DR BERNOTAT-DANIELOWSKI SABINE DR WURZIGER HANNS DR RADDATZ PETER DR MELZER GUIDO DR GANTE JOACHIM DR |
| description | Novel oxazolidinone derivatives of the formula I wherein R is a phenyl radical which is unsubstituted or substituted once by CN, H2N-CH2-, A2N-CH2-, H2N-C(=NH)-, H2N-C(=NH)-NH-, H2N-C(=NH)-NH-CH2-, HO-NH-C(=NH)- or HO-NH-C(=NH)-NH-, X is O, S, SO, SO2, -NH- or -NA-, B is A is alkyl having 1 to 6 C atoms, R is H, A, Li, Na, K, NH4 or benzyl, R is H or (CH2)n-COOR , E in each case independently of one another is CH or N, Q is O, S or NH, m is 1, 2 or 3 and n is 0, 1, 2 or 3, and their physiologically acceptable salts inhibit the binding of fibrinogen to the corresponding receptor and can be used for the treatment of thromboses, apoplexy, cardiac infarct, inflammations, arteriosclerosis, osteoporosis and tumours. |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | OXAZOLIDINONE DERIVATIVE, PROCESS OF ITS PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF |
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