5-substituted-7-[4-(substituted)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidines, their use as anti-rheumatic agents, and pharmaceutical preparations
5-Substituované-7-[4-(substituovaných)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, obecného vzorce I, které jsou účinnými inhibitoy cyklin-dependentních kináz CDK5/7/9, a vykazují silné protizánětlivé účinky. Způsob jejich přípravy, farmaceutické přípravky obsahující tyto sloučeniny a jejich p...
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| creator | Kryštof Vladimír Pospíšil Tomáš Strnad Miroslav Havlíček Libor Šturc Antonín Jorda Radek Vymětalová Ladislava |
| description | 5-Substituované-7-[4-(substituovaných)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, obecného vzorce I, které jsou účinnými inhibitoy cyklin-dependentních kináz CDK5/7/9, a vykazují silné protizánětlivé účinky. Způsob jejich přípravy, farmaceutické přípravky obsahující tyto sloučeniny a jejich použití pro léčbu zánětlivých onemocnění, jako je rheumatoidní arthritida.
The present invention relates to 5-substituted-7-[4-(substituted)benzyl]amino-3- isopropylpyrazolo[4,3-d]pyrimidines of formula (I) which are effective inhibitors od cyclin- dependent kinases and exhibit strong anti-inflammatory properties. This invention further relates to processes for their preparation, to pharmaceutical compositions comprising said compounds and to their use for the treatment of antiiflammatory disorders such as rheumatoid arthritis. |
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The present invention relates to 5-substituted-7-[4-(substituted)benzyl]amino-3- isopropylpyrazolo[4,3-d]pyrimidines of formula (I) which are effective inhibitors od cyclin- dependent kinases and exhibit strong anti-inflammatory properties. This invention further relates to processes for their preparation, to pharmaceutical compositions comprising said compounds and to their use for the treatment of antiiflammatory disorders such as rheumatoid arthritis.</description><language>cze ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170215&DB=EPODOC&CC=CZ&NR=2015509A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25544,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170215&DB=EPODOC&CC=CZ&NR=2015509A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Kryštof Vladimír</creatorcontrib><creatorcontrib>Pospíšil Tomáš</creatorcontrib><creatorcontrib>Strnad Miroslav</creatorcontrib><creatorcontrib>Havlíček Libor</creatorcontrib><creatorcontrib>Šturc Antonín</creatorcontrib><creatorcontrib>Jorda Radek</creatorcontrib><creatorcontrib>Vymětalová Ladislava</creatorcontrib><title>5-substituted-7-[4-(substituted)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidines, their use as anti-rheumatic agents, and pharmaceutical preparations</title><description>5-Substituované-7-[4-(substituovaných)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, obecného vzorce I, které jsou účinnými inhibitoy cyklin-dependentních kináz CDK5/7/9, a vykazují silné protizánětlivé účinky. Způsob jejich přípravy, farmaceutické přípravky obsahující tyto sloučeniny a jejich použití pro léčbu zánětlivých onemocnění, jako je rheumatoidní arthritida.
The present invention relates to 5-substituted-7-[4-(substituted)benzyl]amino-3- isopropylpyrazolo[4,3-d]pyrimidines of formula (I) which are effective inhibitors od cyclin- dependent kinases and exhibit strong anti-inflammatory properties. This invention further relates to processes for their preparation, to pharmaceutical compositions comprising said compounds and to their use for the treatment of antiiflammatory disorders such as rheumatoid arthritis.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNizEKAjEQRbexEPUOKRV2QF0XsZRF8QBWishoRncgm4RMUqwX8bqmsLC0-vz_3h8W7xok3SRyTJE0rOG8gunPMruRffXmgh1bBxWwOB-c743vA76ccedVWYG-5Moda7YkpYotcVBJSKEotJEhtJQ6jHxX-CQbs4NWK99i6PBOKQM0ygfyGLLlrIyLwQON0OSbo0Ltd8fmAOTdlcTnl6V4bU7L-aKu55ttVf2hfAB1D1Hy</recordid><startdate>20170215</startdate><enddate>20170215</enddate><creator>Kryštof Vladimír</creator><creator>Pospíšil Tomáš</creator><creator>Strnad Miroslav</creator><creator>Havlíček Libor</creator><creator>Šturc Antonín</creator><creator>Jorda Radek</creator><creator>Vymětalová Ladislava</creator><scope>EVB</scope></search><sort><creationdate>20170215</creationdate><title>5-substituted-7-[4-(substituted)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidines, their use as anti-rheumatic agents, and pharmaceutical preparations</title><author>Kryštof Vladimír ; Pospíšil Tomáš ; Strnad Miroslav ; Havlíček Libor ; Šturc Antonín ; Jorda Radek ; Vymětalová Ladislava</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CZ2015509A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>cze ; eng</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>Kryštof Vladimír</creatorcontrib><creatorcontrib>Pospíšil Tomáš</creatorcontrib><creatorcontrib>Strnad Miroslav</creatorcontrib><creatorcontrib>Havlíček Libor</creatorcontrib><creatorcontrib>Šturc Antonín</creatorcontrib><creatorcontrib>Jorda Radek</creatorcontrib><creatorcontrib>Vymětalová Ladislava</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Kryštof Vladimír</au><au>Pospíšil Tomáš</au><au>Strnad Miroslav</au><au>Havlíček Libor</au><au>Šturc Antonín</au><au>Jorda Radek</au><au>Vymětalová Ladislava</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>5-substituted-7-[4-(substituted)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidines, their use as anti-rheumatic agents, and pharmaceutical preparations</title><date>2017-02-15</date><risdate>2017</risdate><abstract>5-Substituované-7-[4-(substituovaných)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, obecného vzorce I, které jsou účinnými inhibitoy cyklin-dependentních kináz CDK5/7/9, a vykazují silné protizánětlivé účinky. Způsob jejich přípravy, farmaceutické přípravky obsahující tyto sloučeniny a jejich použití pro léčbu zánětlivých onemocnění, jako je rheumatoidní arthritida.
The present invention relates to 5-substituted-7-[4-(substituted)benzyl]amino-3- isopropylpyrazolo[4,3-d]pyrimidines of formula (I) which are effective inhibitors od cyclin- dependent kinases and exhibit strong anti-inflammatory properties. This invention further relates to processes for their preparation, to pharmaceutical compositions comprising said compounds and to their use for the treatment of antiiflammatory disorders such as rheumatoid arthritis.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 5-substituted-7-[4-(substituted)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidines, their use as anti-rheumatic agents, and pharmaceutical preparations |
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