ΑΝΑΣΤΟΛΕIΣ ΚΙΝΑΣΗΣ ΥΠΟΚΑΤΕΣΤΗΜΕΝΗΣ ΤΡΙΑΖΙΝΗΣ
Η παρούσα εφεύρεση παρέχει ενώσεις υποκατεστημένης 1,3,5-τριαζίνης ως αναστολείς κινάσης και μέθοδο για θεραπεία ή βελτίωση προκαλούμενης από κινάση διαταραχής. The present invention provides substituted 1,3,5-triazine compounds of Formula (I): wherein X, Y and Z are independently selected from the...
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| creator | WANG Aihua EMANUEL Stuart L MIDDLETON Steve A ZHANG Yan DEANGELIS Alan KUO Gee-Hong |
| description | Η παρούσα εφεύρεση παρέχει ενώσεις υποκατεστημένης 1,3,5-τριαζίνης ως αναστολείς κινάσης και μέθοδο για θεραπεία ή βελτίωση προκαλούμενης από κινάση διαταραχής.
The present invention provides substituted 1,3,5-triazine compounds of Formula (I):
wherein
X, Y and Z are independently selected from the group consisting of CH and N; wherein m is an integer from 2 to 5; wherein X, Y and Z include at least one CH atom and at least one N atom; and, wherein a N atom may simultaneously occupy only the X and Z positions;
R 1 is selected from the group consisting of hydrogen and NH 2 ; and,
R 2 is selected from the group consisting of phenyl (wherein phenyl is substituted with one substituent selected from the group consisting of halogen and heterocyclyl) and 1,4-benzodioxinyl;
and pharmaceutically acceptable salts thereof as kinase inhibitors and a method for treating or ameliorating a kinase mediated disorder. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CY1117951TT1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CY1117951TT1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CY1117951TT13</originalsourceid><addsrcrecordid>eNrjZAg5N_HcXCBefG7JufnnZp-b6nluscK5WedmQkWng7hLzy0ASs4CCiw5NxWsdPq5OUDWXIj0knMLgeonnpsG1gUU4mFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8c6RhoaG5pamhiEhhsbEqAEArHFS5Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>ΑΝΑΣΤΟΛΕIΣ ΚΙΝΑΣΗΣ ΥΠΟΚΑΤΕΣΤΗΜΕΝΗΣ ΤΡΙΑΖΙΝΗΣ</title><source>esp@cenet</source><creator>WANG Aihua ; EMANUEL Stuart L ; MIDDLETON Steve A ; ZHANG Yan ; DEANGELIS Alan ; KUO Gee-Hong</creator><creatorcontrib>WANG Aihua ; EMANUEL Stuart L ; MIDDLETON Steve A ; ZHANG Yan ; DEANGELIS Alan ; KUO Gee-Hong</creatorcontrib><description>Η παρούσα εφεύρεση παρέχει ενώσεις υποκατεστημένης 1,3,5-τριαζίνης ως αναστολείς κινάσης και μέθοδο για θεραπεία ή βελτίωση προκαλούμενης από κινάση διαταραχής.
The present invention provides substituted 1,3,5-triazine compounds of Formula (I):
wherein
X, Y and Z are independently selected from the group consisting of CH and N; wherein m is an integer from 2 to 5; wherein X, Y and Z include at least one CH atom and at least one N atom; and, wherein a N atom may simultaneously occupy only the X and Z positions;
R 1 is selected from the group consisting of hydrogen and NH 2 ; and,
R 2 is selected from the group consisting of phenyl (wherein phenyl is substituted with one substituent selected from the group consisting of halogen and heterocyclyl) and 1,4-benzodioxinyl;
and pharmaceutically acceptable salts thereof as kinase inhibitors and a method for treating or ameliorating a kinase mediated disorder.</description><language>Greek</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170517&DB=EPODOC&CC=CY&NR=1117951T1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76419</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170517&DB=EPODOC&CC=CY&NR=1117951T1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WANG Aihua</creatorcontrib><creatorcontrib>EMANUEL Stuart L</creatorcontrib><creatorcontrib>MIDDLETON Steve A</creatorcontrib><creatorcontrib>ZHANG Yan</creatorcontrib><creatorcontrib>DEANGELIS Alan</creatorcontrib><creatorcontrib>KUO Gee-Hong</creatorcontrib><title>ΑΝΑΣΤΟΛΕIΣ ΚΙΝΑΣΗΣ ΥΠΟΚΑΤΕΣΤΗΜΕΝΗΣ ΤΡΙΑΖΙΝΗΣ</title><description>Η παρούσα εφεύρεση παρέχει ενώσεις υποκατεστημένης 1,3,5-τριαζίνης ως αναστολείς κινάσης και μέθοδο για θεραπεία ή βελτίωση προκαλούμενης από κινάση διαταραχής.
The present invention provides substituted 1,3,5-triazine compounds of Formula (I):
wherein
X, Y and Z are independently selected from the group consisting of CH and N; wherein m is an integer from 2 to 5; wherein X, Y and Z include at least one CH atom and at least one N atom; and, wherein a N atom may simultaneously occupy only the X and Z positions;
R 1 is selected from the group consisting of hydrogen and NH 2 ; and,
R 2 is selected from the group consisting of phenyl (wherein phenyl is substituted with one substituent selected from the group consisting of halogen and heterocyclyl) and 1,4-benzodioxinyl;
and pharmaceutically acceptable salts thereof as kinase inhibitors and a method for treating or ameliorating a kinase mediated disorder.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAg5N_HcXCBefG7JufnnZp-b6nluscK5WedmQkWng7hLzy0ASs4CCiw5NxWsdPq5OUDWXIj0knMLgeonnpsG1gUU4mFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8c6RhoaG5pamhiEhhsbEqAEArHFS5Q</recordid><startdate>20170517</startdate><enddate>20170517</enddate><creator>WANG Aihua</creator><creator>EMANUEL Stuart L</creator><creator>MIDDLETON Steve A</creator><creator>ZHANG Yan</creator><creator>DEANGELIS Alan</creator><creator>KUO Gee-Hong</creator><scope>EVB</scope></search><sort><creationdate>20170517</creationdate><title>ΑΝΑΣΤΟΛΕIΣ ΚΙΝΑΣΗΣ ΥΠΟΚΑΤΕΣΤΗΜΕΝΗΣ ΤΡΙΑΖΙΝΗΣ</title><author>WANG Aihua ; EMANUEL Stuart L ; MIDDLETON Steve A ; ZHANG Yan ; DEANGELIS Alan ; KUO Gee-Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CY1117951TT13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>Greek</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>WANG Aihua</creatorcontrib><creatorcontrib>EMANUEL Stuart L</creatorcontrib><creatorcontrib>MIDDLETON Steve A</creatorcontrib><creatorcontrib>ZHANG Yan</creatorcontrib><creatorcontrib>DEANGELIS Alan</creatorcontrib><creatorcontrib>KUO Gee-Hong</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WANG Aihua</au><au>EMANUEL Stuart L</au><au>MIDDLETON Steve A</au><au>ZHANG Yan</au><au>DEANGELIS Alan</au><au>KUO Gee-Hong</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ΑΝΑΣΤΟΛΕIΣ ΚΙΝΑΣΗΣ ΥΠΟΚΑΤΕΣΤΗΜΕΝΗΣ ΤΡΙΑΖΙΝΗΣ</title><date>2017-05-17</date><risdate>2017</risdate><abstract>Η παρούσα εφεύρεση παρέχει ενώσεις υποκατεστημένης 1,3,5-τριαζίνης ως αναστολείς κινάσης και μέθοδο για θεραπεία ή βελτίωση προκαλούμενης από κινάση διαταραχής.
The present invention provides substituted 1,3,5-triazine compounds of Formula (I):
wherein
X, Y and Z are independently selected from the group consisting of CH and N; wherein m is an integer from 2 to 5; wherein X, Y and Z include at least one CH atom and at least one N atom; and, wherein a N atom may simultaneously occupy only the X and Z positions;
R 1 is selected from the group consisting of hydrogen and NH 2 ; and,
R 2 is selected from the group consisting of phenyl (wherein phenyl is substituted with one substituent selected from the group consisting of halogen and heterocyclyl) and 1,4-benzodioxinyl;
and pharmaceutically acceptable salts thereof as kinase inhibitors and a method for treating or ameliorating a kinase mediated disorder.</abstract><oa>free_for_read</oa></addata></record> |
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| language | Greek |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ΑΝΑΣΤΟΛΕIΣ ΚΙΝΑΣΗΣ ΥΠΟΚΑΤΕΣΤΗΜΕΝΗΣ ΤΡΙΑΖΙΝΗΣ |
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