ΣΠΕΙΡΟΚΥΚΛΙΚΑ ΠΑΡΑΓΩΓΑ ΚΥΚΛΟΕΞΑΝΙΟΥ
Η παρούσα εφεύρεση αφορά σε σπειροκυκλικά παράγωγα κυκλοεξανίου, μεθόδους για την παρασκευή τους, φάρμακα που περιέχουν τις ενώσεις αυτές και τη χρησιμοποίηση σπειροκυκλικών παραγώγων κυκλοεξανίου για την παρασκευή φαρμάκων. Spiro-((4-amino-cyclohexane)-1,1'-1',3',4',9'-tetr...
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| creator | FRIEDERICHS Elmar Dr ROSE Valerie Sarah Dr KÖGEL Babette-Yvonne Dr HENKEL Birgitta Dr HINZE Claudia Dr LINZ Klaus Dr LIPKIN Michael Jonathen Dr ENGLBERGER Werner Dr OBERBÖRSCH Stefan Dr SUNDERMANN Bernd Dr SCHICK Hans Dr Prof AULENBACHER Otto SONNENSCHEIN Helmut Dr |
| description | Η παρούσα εφεύρεση αφορά σε σπειροκυκλικά παράγωγα κυκλοεξανίου, μεθόδους για την παρασκευή τους, φάρμακα που περιέχουν τις ενώσεις αυτές και τη χρησιμοποίηση σπειροκυκλικών παραγώγων κυκλοεξανίου για την παρασκευή φαρμάκων.
Spiro-((4-amino-cyclohexane)-1,1'-1',3',4',9'-tetrahydropyrano-(3,4-b)-indole) derivatives (I) are new. Spiro-cyclic cyclohexylamine derivatives of formula (I), optionally in the form of racemates, pure stereoisomers (especially enantiomers or diastereomers) or their mixtures in all proportions, including free bases, free acids, salts (specifically acid or base addition salt) or solvates (specifically hydrates), are new. [Image] R 1, R 2 : H, optionally unsaturated, optionally mono- or polysubstituted 1-4C alkyl or CHO; R 3 : -(CH 2) n-Aryl; n : 0-2; R 4 : H, optionally unsaturated, optionally mono- or polysubstituted 1-3C alkyl or -CO-(CH 2) m-H; m : 0-2; R 5 - R 8 : H; 1-5C alkyl or 1-3C alkoxy (both optionally unsaturated and optionally mono- or polysubstituted); or halo, OH, SH, SMe, OMe, NH 2, COOH, COOMe, NHMe, NMe 2 or NO 2. ACTIVITY : Analgesic; Tranquilizer; Antidepressant; Anticonvulsant; Neuroprotective; Nootropic; Antiaddictive; Antialcoholic; Vasotropic; Cardiant; Hypotensive; Hypertensive; Auditory; Antipruritic; Antimigraine; Laxative; Anorectic; Antidiarrheic; Immunomodulator; Uropathic; Relaxant; Anesthetic; Diuretic. The hydrochloride of the non-polar diastereomer of 1,1-(3-dimethylamino-3-phenyl-pentamethylene)-1,3,4,9-tetrahydropyrano-(3,4-b)-indole) (Ia) had analgesic ED 5 0 3.5 MicroM i.v. in the mouse tail-flick test. MECHANISM OF ACTION : Nociceptin/ORL1 receptor (opioid receptor like-receptor 1) system modulator; ORL1 receptor ligand. |
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Spiro-((4-amino-cyclohexane)-1,1'-1',3',4',9'-tetrahydropyrano-(3,4-b)-indole) derivatives (I) are new. Spiro-cyclic cyclohexylamine derivatives of formula (I), optionally in the form of racemates, pure stereoisomers (especially enantiomers or diastereomers) or their mixtures in all proportions, including free bases, free acids, salts (specifically acid or base addition salt) or solvates (specifically hydrates), are new. [Image] R 1, R 2 : H, optionally unsaturated, optionally mono- or polysubstituted 1-4C alkyl or CHO; R 3 : -(CH 2) n-Aryl; n : 0-2; R 4 : H, optionally unsaturated, optionally mono- or polysubstituted 1-3C alkyl or -CO-(CH 2) m-H; m : 0-2; R 5 - R 8 : H; 1-5C alkyl or 1-3C alkoxy (both optionally unsaturated and optionally mono- or polysubstituted); or halo, OH, SH, SMe, OMe, NH 2, COOH, COOMe, NHMe, NMe 2 or NO 2. ACTIVITY : Analgesic; Tranquilizer; Antidepressant; Anticonvulsant; Neuroprotective; Nootropic; Antiaddictive; Antialcoholic; Vasotropic; Cardiant; Hypotensive; Hypertensive; Auditory; Antipruritic; Antimigraine; Laxative; Anorectic; Antidiarrheic; Immunomodulator; Uropathic; Relaxant; Anesthetic; Diuretic. The hydrochloride of the non-polar diastereomer of 1,1-(3-dimethylamino-3-phenyl-pentamethylene)-1,3,4,9-tetrahydropyrano-(3,4-b)-indole) (Ia) had analgesic ED 5 0 3.5 MicroM i.v. in the mouse tail-flick test. MECHANISM OF ACTION : Nociceptin/ORL1 receptor (opioid receptor like-receptor 1) system modulator; ORL1 receptor ligand.</description><language>Greek</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20161005&DB=EPODOC&CC=CY&NR=1114616T1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20161005&DB=EPODOC&CC=CY&NR=1114616T1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FRIEDERICHS Elmar Dr</creatorcontrib><creatorcontrib>ROSE Valerie Sarah Dr</creatorcontrib><creatorcontrib>KÖGEL Babette-Yvonne Dr</creatorcontrib><creatorcontrib>HENKEL Birgitta Dr</creatorcontrib><creatorcontrib>HINZE Claudia Dr</creatorcontrib><creatorcontrib>LINZ Klaus Dr</creatorcontrib><creatorcontrib>LIPKIN Michael Jonathen Dr</creatorcontrib><creatorcontrib>ENGLBERGER Werner Dr</creatorcontrib><creatorcontrib>OBERBÖRSCH Stefan Dr</creatorcontrib><creatorcontrib>SUNDERMANN Bernd Dr</creatorcontrib><creatorcontrib>SCHICK Hans Dr Prof</creatorcontrib><creatorcontrib>AULENBACHER Otto</creatorcontrib><creatorcontrib>SONNENSCHEIN Helmut Dr</creatorcontrib><title>ΣΠΕΙΡΟΚΥΚΛΙΚΑ ΠΑΡΑΓΩΓΑ ΚΥΚΛΟΕΞΑΝΙΟΥ</title><description>Η παρούσα εφεύρεση αφορά σε σπειροκυκλικά παράγωγα κυκλοεξανίου, μεθόδους για την παρασκευή τους, φάρμακα που περιέχουν τις ενώσεις αυτές και τη χρησιμοποίηση σπειροκυκλικών παραγώγων κυκλοεξανίου για την παρασκευή φαρμάκων.
Spiro-((4-amino-cyclohexane)-1,1'-1',3',4',9'-tetrahydropyrano-(3,4-b)-indole) derivatives (I) are new. Spiro-cyclic cyclohexylamine derivatives of formula (I), optionally in the form of racemates, pure stereoisomers (especially enantiomers or diastereomers) or their mixtures in all proportions, including free bases, free acids, salts (specifically acid or base addition salt) or solvates (specifically hydrates), are new. [Image] R 1, R 2 : H, optionally unsaturated, optionally mono- or polysubstituted 1-4C alkyl or CHO; R 3 : -(CH 2) n-Aryl; n : 0-2; R 4 : H, optionally unsaturated, optionally mono- or polysubstituted 1-3C alkyl or -CO-(CH 2) m-H; m : 0-2; R 5 - R 8 : H; 1-5C alkyl or 1-3C alkoxy (both optionally unsaturated and optionally mono- or polysubstituted); or halo, OH, SH, SMe, OMe, NH 2, COOH, COOMe, NHMe, NMe 2 or NO 2. ACTIVITY : Analgesic; Tranquilizer; Antidepressant; Anticonvulsant; Neuroprotective; Nootropic; Antiaddictive; Antialcoholic; Vasotropic; Cardiant; Hypotensive; Hypertensive; Auditory; Antipruritic; Antimigraine; Laxative; Anorectic; Antidiarrheic; Immunomodulator; Uropathic; Relaxant; Anesthetic; Diuretic. The hydrochloride of the non-polar diastereomer of 1,1-(3-dimethylamino-3-phenyl-pentamethylene)-1,3,4,9-tetrahydropyrano-(3,4-b)-indole) (Ia) had analgesic ED 5 0 3.5 MicroM i.v. in the mouse tail-flick test. MECHANISM OF ACTION : Nociceptin/ORL1 receptor (opioid receptor like-receptor 1) system modulator; ORL1 receptor ligand.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHA5t_jcgnNTz808t_Dc_HOzzi0F4tlA3qxzExWAEhOBwhPPTT63EoiBAjD5-UAd84ASc4Eq559bysPAmpaYU5zKC6W5GRTdXEOcPXRTC_LjU4sLEpNT81JL4p0jDQ0NTcwMzUJCDI2JUQMA57BIZA</recordid><startdate>20161005</startdate><enddate>20161005</enddate><creator>FRIEDERICHS Elmar Dr</creator><creator>ROSE Valerie Sarah Dr</creator><creator>KÖGEL Babette-Yvonne Dr</creator><creator>HENKEL Birgitta Dr</creator><creator>HINZE Claudia Dr</creator><creator>LINZ Klaus Dr</creator><creator>LIPKIN Michael Jonathen Dr</creator><creator>ENGLBERGER Werner Dr</creator><creator>OBERBÖRSCH Stefan Dr</creator><creator>SUNDERMANN Bernd Dr</creator><creator>SCHICK Hans Dr Prof</creator><creator>AULENBACHER Otto</creator><creator>SONNENSCHEIN Helmut Dr</creator><scope>EVB</scope></search><sort><creationdate>20161005</creationdate><title>ΣΠΕΙΡΟΚΥΚΛΙΚΑ ΠΑΡΑΓΩΓΑ ΚΥΚΛΟΕΞΑΝΙΟΥ</title><author>FRIEDERICHS Elmar Dr ; ROSE Valerie Sarah Dr ; KÖGEL Babette-Yvonne Dr ; HENKEL Birgitta Dr ; HINZE Claudia Dr ; LINZ Klaus Dr ; LIPKIN Michael Jonathen Dr ; ENGLBERGER Werner Dr ; OBERBÖRSCH Stefan Dr ; SUNDERMANN Bernd Dr ; SCHICK Hans Dr Prof ; AULENBACHER Otto ; SONNENSCHEIN Helmut Dr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CY1114616TT13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>Greek</language><creationdate>2016</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>FRIEDERICHS Elmar Dr</creatorcontrib><creatorcontrib>ROSE Valerie Sarah Dr</creatorcontrib><creatorcontrib>KÖGEL Babette-Yvonne Dr</creatorcontrib><creatorcontrib>HENKEL Birgitta Dr</creatorcontrib><creatorcontrib>HINZE Claudia Dr</creatorcontrib><creatorcontrib>LINZ Klaus Dr</creatorcontrib><creatorcontrib>LIPKIN Michael Jonathen Dr</creatorcontrib><creatorcontrib>ENGLBERGER Werner Dr</creatorcontrib><creatorcontrib>OBERBÖRSCH Stefan Dr</creatorcontrib><creatorcontrib>SUNDERMANN Bernd Dr</creatorcontrib><creatorcontrib>SCHICK Hans Dr Prof</creatorcontrib><creatorcontrib>AULENBACHER Otto</creatorcontrib><creatorcontrib>SONNENSCHEIN Helmut Dr</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>FRIEDERICHS Elmar Dr</au><au>ROSE Valerie Sarah Dr</au><au>KÖGEL Babette-Yvonne Dr</au><au>HENKEL Birgitta Dr</au><au>HINZE Claudia Dr</au><au>LINZ Klaus Dr</au><au>LIPKIN Michael Jonathen Dr</au><au>ENGLBERGER Werner Dr</au><au>OBERBÖRSCH Stefan Dr</au><au>SUNDERMANN Bernd Dr</au><au>SCHICK Hans Dr Prof</au><au>AULENBACHER Otto</au><au>SONNENSCHEIN Helmut Dr</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ΣΠΕΙΡΟΚΥΚΛΙΚΑ ΠΑΡΑΓΩΓΑ ΚΥΚΛΟΕΞΑΝΙΟΥ</title><date>2016-10-05</date><risdate>2016</risdate><abstract>Η παρούσα εφεύρεση αφορά σε σπειροκυκλικά παράγωγα κυκλοεξανίου, μεθόδους για την παρασκευή τους, φάρμακα που περιέχουν τις ενώσεις αυτές και τη χρησιμοποίηση σπειροκυκλικών παραγώγων κυκλοεξανίου για την παρασκευή φαρμάκων.
Spiro-((4-amino-cyclohexane)-1,1'-1',3',4',9'-tetrahydropyrano-(3,4-b)-indole) derivatives (I) are new. Spiro-cyclic cyclohexylamine derivatives of formula (I), optionally in the form of racemates, pure stereoisomers (especially enantiomers or diastereomers) or their mixtures in all proportions, including free bases, free acids, salts (specifically acid or base addition salt) or solvates (specifically hydrates), are new. [Image] R 1, R 2 : H, optionally unsaturated, optionally mono- or polysubstituted 1-4C alkyl or CHO; R 3 : -(CH 2) n-Aryl; n : 0-2; R 4 : H, optionally unsaturated, optionally mono- or polysubstituted 1-3C alkyl or -CO-(CH 2) m-H; m : 0-2; R 5 - R 8 : H; 1-5C alkyl or 1-3C alkoxy (both optionally unsaturated and optionally mono- or polysubstituted); or halo, OH, SH, SMe, OMe, NH 2, COOH, COOMe, NHMe, NMe 2 or NO 2. ACTIVITY : Analgesic; Tranquilizer; Antidepressant; Anticonvulsant; Neuroprotective; Nootropic; Antiaddictive; Antialcoholic; Vasotropic; Cardiant; Hypotensive; Hypertensive; Auditory; Antipruritic; Antimigraine; Laxative; Anorectic; Antidiarrheic; Immunomodulator; Uropathic; Relaxant; Anesthetic; Diuretic. The hydrochloride of the non-polar diastereomer of 1,1-(3-dimethylamino-3-phenyl-pentamethylene)-1,3,4,9-tetrahydropyrano-(3,4-b)-indole) (Ia) had analgesic ED 5 0 3.5 MicroM i.v. in the mouse tail-flick test. MECHANISM OF ACTION : Nociceptin/ORL1 receptor (opioid receptor like-receptor 1) system modulator; ORL1 receptor ligand.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ΣΠΕΙΡΟΚΥΚΛΙΚΑ ΠΑΡΑΓΩΓΑ ΚΥΚΛΟΕΞΑΝΙΟΥ |
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