ANTICUERPOS ANTI-PMEL 17 Y CONJUGADOS DE LOS MISMOS

La presente solicitud describe anticuerpos anti-PMEL 17, fragmentos de unión a antígeno de los mismos, y conjugados de anticuerpo fármaco de dichos anticuerpos o fragmentos de unión a antígeno conjugados a un inhibidor de GNAQ/GNA11. Además, se describe un proceso de preparación de anticuerpos, frag...

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Hauptverfasser: D'Alessio, Joseph Anthony, Robles, Eusebio Manchado, Fleming, Tony, Burger, Matthew, Rauniyar, Vivek
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creator D'Alessio, Joseph Anthony
Robles, Eusebio Manchado
Fleming, Tony
Burger, Matthew
Rauniyar, Vivek
description La presente solicitud describe anticuerpos anti-PMEL 17, fragmentos de unión a antígeno de los mismos, y conjugados de anticuerpo fármaco de dichos anticuerpos o fragmentos de unión a antígeno conjugados a un inhibidor de GNAQ/GNA11. Además, se describe un proceso de preparación de anticuerpos, fragmentos de unión a antígeno, y conjugados de anticuerpo fármaco. This application discloses anti-PMEL17 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title ANTICUERPOS ANTI-PMEL 17 Y CONJUGADOS DE LOS MISMOS
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