COMPUESTOS TETRÁMEROS CÍCLICOS COMO INHIBIDORES DE PROPROTEÍNA CONVERTASA SUBTILISINA/KEXINA TIPO 9 (PCSK9) PARA EL TRATAMIENTO DE TRASTORNOS METABÓLICOS
La invención se refiere a compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (PCSK9) de utilidad en el tratamiento del metabolismo de los lípidos del colesterol y otras enfermedades en las que PCSK9 interviene, que tienen la fórmula (I): Espacio para...
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| creator | Yang, Lihua Grosche, Philipp Briner, Karin Mao, Justin Yik Ching Su, Liansheng Dechristopher, Brian Addison Zheng, Rui Patel, Tajesh Jayprakash Liu, Eugene Yuejin Monovich, Lauren Gilchrist Flyer, Alec Nathanson Sanchez, Carina Cristina Golosov, Andrei Alexandrovich |
| description | La invención se refiere a compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (PCSK9) de utilidad en el tratamiento del metabolismo de los lípidos del colesterol y otras enfermedades en las que PCSK9 interviene, que tienen la fórmula (I): Espacio para la fórmula. en donde R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2 y X3 están descriptos en la presente.
The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I):or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2, and X3 are described herein. |
| format | Patent |
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The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I):or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2, and X3 are described herein.</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220113&DB=EPODOC&CC=CU&NR=20210043A7$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220113&DB=EPODOC&CC=CU&NR=20210043A7$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Yang, Lihua</creatorcontrib><creatorcontrib>Grosche, Philipp</creatorcontrib><creatorcontrib>Briner, Karin</creatorcontrib><creatorcontrib>Mao, Justin Yik Ching</creatorcontrib><creatorcontrib>Su, Liansheng</creatorcontrib><creatorcontrib>Dechristopher, Brian Addison</creatorcontrib><creatorcontrib>Zheng, Rui</creatorcontrib><creatorcontrib>Patel, Tajesh Jayprakash</creatorcontrib><creatorcontrib>Liu, Eugene Yuejin</creatorcontrib><creatorcontrib>Monovich, Lauren Gilchrist</creatorcontrib><creatorcontrib>Flyer, Alec Nathanson</creatorcontrib><creatorcontrib>Sanchez, Carina Cristina</creatorcontrib><creatorcontrib>Golosov, Andrei Alexandrovich</creatorcontrib><title>COMPUESTOS TETRÁMEROS CÍCLICOS COMO INHIBIDORES DE PROPROTEÍNA CONVERTASA SUBTILISINA/KEXINA TIPO 9 (PCSK9) PARA EL TRATAMIENTO DE TRASTORNOS METABÓLICOS</title><description>La invención se refiere a compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (PCSK9) de utilidad en el tratamiento del metabolismo de los lípidos del colesterol y otras enfermedades en las que PCSK9 interviene, que tienen la fórmula (I): Espacio para la fórmula. en donde R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2 y X3 están descriptos en la presente.
The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I):or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2, and X3 are described herein.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNTjuqAkEQ3MRA1Du0mQbi6gpi2Dv2w8adDzO9YiYiYyQq6AXeAYyMPc1e7I0PDyAUVBUUVdXOXspqV1MQG0BIfPOrySetmoeqWL2V1RbYrLjkpfUUYEngvE0Qah4GU8BsyAsGhFCXwhUHNjhe0zYRCDsLCxg4FdaLITj0CFSBeBTUTEbsuzDZdMGbtKdJsGye_-PdrHXcn26x9-FO1v8hUatRvF528XbdH-I53neqnubTSZ7PCpwX32T-ADB-R34</recordid><startdate>20220113</startdate><enddate>20220113</enddate><creator>Yang, Lihua</creator><creator>Grosche, Philipp</creator><creator>Briner, Karin</creator><creator>Mao, Justin Yik Ching</creator><creator>Su, Liansheng</creator><creator>Dechristopher, Brian Addison</creator><creator>Zheng, Rui</creator><creator>Patel, Tajesh Jayprakash</creator><creator>Liu, Eugene Yuejin</creator><creator>Monovich, Lauren Gilchrist</creator><creator>Flyer, Alec Nathanson</creator><creator>Sanchez, Carina Cristina</creator><creator>Golosov, Andrei Alexandrovich</creator><scope>EVB</scope></search><sort><creationdate>20220113</creationdate><title>COMPUESTOS TETRÁMEROS CÍCLICOS COMO INHIBIDORES DE PROPROTEÍNA CONVERTASA SUBTILISINA/KEXINA TIPO 9 (PCSK9) PARA EL TRATAMIENTO DE TRASTORNOS METABÓLICOS</title><author>Yang, Lihua ; Grosche, Philipp ; Briner, Karin ; Mao, Justin Yik Ching ; Su, Liansheng ; Dechristopher, Brian Addison ; Zheng, Rui ; Patel, Tajesh Jayprakash ; Liu, Eugene Yuejin ; Monovich, Lauren Gilchrist ; Flyer, Alec Nathanson ; Sanchez, Carina Cristina ; Golosov, Andrei Alexandrovich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CU20210043A73</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>Yang, Lihua</creatorcontrib><creatorcontrib>Grosche, Philipp</creatorcontrib><creatorcontrib>Briner, Karin</creatorcontrib><creatorcontrib>Mao, Justin Yik Ching</creatorcontrib><creatorcontrib>Su, Liansheng</creatorcontrib><creatorcontrib>Dechristopher, Brian Addison</creatorcontrib><creatorcontrib>Zheng, Rui</creatorcontrib><creatorcontrib>Patel, Tajesh Jayprakash</creatorcontrib><creatorcontrib>Liu, Eugene Yuejin</creatorcontrib><creatorcontrib>Monovich, Lauren Gilchrist</creatorcontrib><creatorcontrib>Flyer, Alec Nathanson</creatorcontrib><creatorcontrib>Sanchez, Carina Cristina</creatorcontrib><creatorcontrib>Golosov, Andrei Alexandrovich</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Yang, Lihua</au><au>Grosche, Philipp</au><au>Briner, Karin</au><au>Mao, Justin Yik Ching</au><au>Su, Liansheng</au><au>Dechristopher, Brian Addison</au><au>Zheng, Rui</au><au>Patel, Tajesh Jayprakash</au><au>Liu, Eugene Yuejin</au><au>Monovich, Lauren Gilchrist</au><au>Flyer, Alec Nathanson</au><au>Sanchez, Carina Cristina</au><au>Golosov, Andrei Alexandrovich</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPUESTOS TETRÁMEROS CÍCLICOS COMO INHIBIDORES DE PROPROTEÍNA CONVERTASA SUBTILISINA/KEXINA TIPO 9 (PCSK9) PARA EL TRATAMIENTO DE TRASTORNOS METABÓLICOS</title><date>2022-01-13</date><risdate>2022</risdate><abstract>La invención se refiere a compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (PCSK9) de utilidad en el tratamiento del metabolismo de los lípidos del colesterol y otras enfermedades en las que PCSK9 interviene, que tienen la fórmula (I): Espacio para la fórmula. en donde R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2 y X3 están descriptos en la presente.
The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I):or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2, and X3 are described herein.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | COMPUESTOS TETRÁMEROS CÍCLICOS COMO INHIBIDORES DE PROPROTEÍNA CONVERTASA SUBTILISINA/KEXINA TIPO 9 (PCSK9) PARA EL TRATAMIENTO DE TRASTORNOS METABÓLICOS |
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