METHOD OF SELEGILINE'S HYDROCHLORIDE PRODUCTION
The present invention relates to a new method for preparing selegiline hydrochloride, particularly in the form of its (R)-(-)-enantiomer. Selegiline hydrochloride is a highly potent antiparkinsonic agent with low toxicity. The method of the invention consists in that 2-methylamino-1-phenylpropane is...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | FERENC MILAN RNDR.,CS POSPISIL JOSEF,CS HAJICEK JOSEF CSC.,CS HRBATA JIRI PHARM. DR.,CS KREPELKA JIRI CSC.,CS PIHERA PAVEL,CS KVAPIL LUBOMIR RNDR.,CS BRUNOVA BOHUMILA CSC.,CS |
| description | The present invention relates to a new method for preparing selegiline hydrochloride, particularly in the form of its (R)-(-)-enantiomer. Selegiline hydrochloride is a highly potent antiparkinsonic agent with low toxicity. The method of the invention consists in that 2-methylamino-1-phenylpropane is reacted with propargyl bromide and potassium carbonate, both in a molar excess of at least 10 %, based on the amount of 2-methylamino-1-phenylpropane, equivalent, with use of chloroform, methylene chloride, methanol or dimethylformamide as solvent, at a temperature within the range of from +5 DEG C to the boiling temperature of the reaction mixture; the formed base is converted into the hydrochloride using hydrogen chloride in isopropanol. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CS370788A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CS370788A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CS370788A13</originalsourceid><addsrcrecordid>eNrjZND3dQ3x8HdR8HdTCHb1cXX39PH0c1UPVvCIdAnyd_bw8Q_ydHFVCAjydwl1DvH09-NhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfHOwcbmBuYWFo6GxoRVAACBHiVo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>METHOD OF SELEGILINE'S HYDROCHLORIDE PRODUCTION</title><source>esp@cenet</source><creator>FERENC MILAN RNDR.,CS ; POSPISIL JOSEF,CS ; HAJICEK JOSEF CSC.,CS ; HRBATA JIRI PHARM. DR.,CS ; KREPELKA JIRI CSC.,CS ; PIHERA PAVEL,CS ; KVAPIL LUBOMIR RNDR.,CS ; BRUNOVA BOHUMILA CSC.,CS</creator><creatorcontrib>FERENC MILAN RNDR.,CS ; POSPISIL JOSEF,CS ; HAJICEK JOSEF CSC.,CS ; HRBATA JIRI PHARM. DR.,CS ; KREPELKA JIRI CSC.,CS ; PIHERA PAVEL,CS ; KVAPIL LUBOMIR RNDR.,CS ; BRUNOVA BOHUMILA CSC.,CS</creatorcontrib><description>The present invention relates to a new method for preparing selegiline hydrochloride, particularly in the form of its (R)-(-)-enantiomer. Selegiline hydrochloride is a highly potent antiparkinsonic agent with low toxicity. The method of the invention consists in that 2-methylamino-1-phenylpropane is reacted with propargyl bromide and potassium carbonate, both in a molar excess of at least 10 %, based on the amount of 2-methylamino-1-phenylpropane, equivalent, with use of chloroform, methylene chloride, methanol or dimethylformamide as solvent, at a temperature within the range of from +5 DEG C to the boiling temperature of the reaction mixture; the formed base is converted into the hydrochloride using hydrogen chloride in isopropanol.</description><edition>4</edition><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1989</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19890912&DB=EPODOC&CC=CS&NR=370788A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19890912&DB=EPODOC&CC=CS&NR=370788A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FERENC MILAN RNDR.,CS</creatorcontrib><creatorcontrib>POSPISIL JOSEF,CS</creatorcontrib><creatorcontrib>HAJICEK JOSEF CSC.,CS</creatorcontrib><creatorcontrib>HRBATA JIRI PHARM. DR.,CS</creatorcontrib><creatorcontrib>KREPELKA JIRI CSC.,CS</creatorcontrib><creatorcontrib>PIHERA PAVEL,CS</creatorcontrib><creatorcontrib>KVAPIL LUBOMIR RNDR.,CS</creatorcontrib><creatorcontrib>BRUNOVA BOHUMILA CSC.,CS</creatorcontrib><title>METHOD OF SELEGILINE'S HYDROCHLORIDE PRODUCTION</title><description>The present invention relates to a new method for preparing selegiline hydrochloride, particularly in the form of its (R)-(-)-enantiomer. Selegiline hydrochloride is a highly potent antiparkinsonic agent with low toxicity. The method of the invention consists in that 2-methylamino-1-phenylpropane is reacted with propargyl bromide and potassium carbonate, both in a molar excess of at least 10 %, based on the amount of 2-methylamino-1-phenylpropane, equivalent, with use of chloroform, methylene chloride, methanol or dimethylformamide as solvent, at a temperature within the range of from +5 DEG C to the boiling temperature of the reaction mixture; the formed base is converted into the hydrochloride using hydrogen chloride in isopropanol.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1989</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZND3dQ3x8HdR8HdTCHb1cXX39PH0c1UPVvCIdAnyd_bw8Q_ydHFVCAjydwl1DvH09-NhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfHOwcbmBuYWFo6GxoRVAACBHiVo</recordid><startdate>19890912</startdate><enddate>19890912</enddate><creator>FERENC MILAN RNDR.,CS</creator><creator>POSPISIL JOSEF,CS</creator><creator>HAJICEK JOSEF CSC.,CS</creator><creator>HRBATA JIRI PHARM. DR.,CS</creator><creator>KREPELKA JIRI CSC.,CS</creator><creator>PIHERA PAVEL,CS</creator><creator>KVAPIL LUBOMIR RNDR.,CS</creator><creator>BRUNOVA BOHUMILA CSC.,CS</creator><scope>EVB</scope></search><sort><creationdate>19890912</creationdate><title>METHOD OF SELEGILINE'S HYDROCHLORIDE PRODUCTION</title><author>FERENC MILAN RNDR.,CS ; POSPISIL JOSEF,CS ; HAJICEK JOSEF CSC.,CS ; HRBATA JIRI PHARM. DR.,CS ; KREPELKA JIRI CSC.,CS ; PIHERA PAVEL,CS ; KVAPIL LUBOMIR RNDR.,CS ; BRUNOVA BOHUMILA CSC.,CS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CS370788A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1989</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>FERENC MILAN RNDR.,CS</creatorcontrib><creatorcontrib>POSPISIL JOSEF,CS</creatorcontrib><creatorcontrib>HAJICEK JOSEF CSC.,CS</creatorcontrib><creatorcontrib>HRBATA JIRI PHARM. DR.,CS</creatorcontrib><creatorcontrib>KREPELKA JIRI CSC.,CS</creatorcontrib><creatorcontrib>PIHERA PAVEL,CS</creatorcontrib><creatorcontrib>KVAPIL LUBOMIR RNDR.,CS</creatorcontrib><creatorcontrib>BRUNOVA BOHUMILA CSC.,CS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>FERENC MILAN RNDR.,CS</au><au>POSPISIL JOSEF,CS</au><au>HAJICEK JOSEF CSC.,CS</au><au>HRBATA JIRI PHARM. DR.,CS</au><au>KREPELKA JIRI CSC.,CS</au><au>PIHERA PAVEL,CS</au><au>KVAPIL LUBOMIR RNDR.,CS</au><au>BRUNOVA BOHUMILA CSC.,CS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD OF SELEGILINE'S HYDROCHLORIDE PRODUCTION</title><date>1989-09-12</date><risdate>1989</risdate><abstract>The present invention relates to a new method for preparing selegiline hydrochloride, particularly in the form of its (R)-(-)-enantiomer. Selegiline hydrochloride is a highly potent antiparkinsonic agent with low toxicity. The method of the invention consists in that 2-methylamino-1-phenylpropane is reacted with propargyl bromide and potassium carbonate, both in a molar excess of at least 10 %, based on the amount of 2-methylamino-1-phenylpropane, equivalent, with use of chloroform, methylene chloride, methanol or dimethylformamide as solvent, at a temperature within the range of from +5 DEG C to the boiling temperature of the reaction mixture; the formed base is converted into the hydrochloride using hydrogen chloride in isopropanol.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_CS370788A1 |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | METHOD OF SELEGILINE'S HYDROCHLORIDE PRODUCTION |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T20%3A46%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=FERENC%20MILAN%20RNDR.,CS&rft.date=1989-09-12&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECS370788A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |