METHOD OF ERGOLEN DERIVATIVES PRODUCTION

METHOD OF ERGOLEN DERIVATIVES PRODUCTION

The invention relates to novel 2-halogenated 8- and 1,8-substituted ergolene derivatives of the formula (I) and the acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the formula (I) (I) wherein X stands for a halogen; R stands for a C1-4...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MEGYERI GABOR ,HU, LASZLOVSZKY ISTVAN DR.,HU, GROO DORA DR.,HU, KASSAI ANNA,HU, STEFKO BELA DR.,HU, PALOSI EVA DR.,HU, KOVACS LAJOS ,HU, KISS BELA,HU, SZPORNY LASZLO DR.,HU, LAPIS ERZSEBET ,HU, KEVE TIBOR DR.,HU
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to novel 2-halogenated 8- and 1,8-substituted ergolene derivatives of the formula (I) and the acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the formula (I) (I) wherein X stands for a halogen; R stands for a C1-4 alkyl group and R'' means a hydroxyl group; or R stands for an acyl or substituted acyl group and R'' represents a halogen or an -OR' group, wherein R' stands for an acyl or substituted acyl group; or R stands for hydrogen and R'' means a halogen or an -OR' group, wherein R' stands for an acyl or substituted acyl group; and the dotted line means a double bond between the 8-9 or 9-10 positions. The compounds of the formula (I) possess an antipsychotic and antihypoxic action and a negligable extrapyramidal side-effect.