METHOD OF 2-(TETRAHYDRO-2-FURFURYL)-3-(1-NAPHTHYL)-PROPANOIC ACID PREPARATION

Solution concerns the method of the preparation of 2-/tetrahydro-2-furfuryl/-3-/1-naftyl/propanoic acid of formula I by alkaline hydrolysis of dialkyl esters of 1-/tetrahydro-2-furyl/-3-/1-naftyl-2.2-propandicarboxylic acid of the general formula III, in which R means methyl or ethyl group and subsequent thermic decarboxylation of corresponding alkaline salts and/or of dicarboxylic acid of the general formula II, in which R means the atom of sodium, potassium, or hydrogen in mineral acid and in an aprotic solvent. The solution makes it possible to execute a one-step synthesis of the required substance of the formula I, without isolation of intermediate products. The substance of the formula I serves as an intermediate product in the preparation of pharmaceutical with vasodilatative and nootropic effects in human medicine