METHOD OF NEW RACEMIC OR OPTICALLY ACTIVE BERBANE DERIVATIVES PRODUCTION
The invention relates to novel racemic or optically active berban derivatives of the general formula (I), whereinR' and R2 represent independently from the other a hydroxyl, straight or branched chain alkoxy group having 1 to 6 carbon atoms or R' and R7 together represent a C1-3 alkylenedi...
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| creator | GAAL JOZSEF DR.,HU TOTH ISTVAN ,HU SZABO LAJOS ,HU VIZI SZILVESZTER DR.,HU SOMOGYI GYORGY ,HU KOVACS GABOR ,HU HARSING LASZLO ,HU MARTON JENO DR.,HU SZANTAI CSABA ,HU |
| description | The invention relates to novel racemic or optically active berban derivatives of the general formula (I), whereinR' and R2 represent independently from the other a hydroxyl, straight or branched chain alkoxy group having 1 to 6 carbon atoms or R' and R7 together represent a C1-3 alkylenedioxy group;R3 and R4 represent independently from the other hydrogen, straight or branched chain alkyl group, having 1 to 4 carbon atoms and optionally substituted by hydroxyl group, or a C2-6 alkoxycarbonyl or cyano group; andR5 represents hydrogen, straight or branched chain alkyl group having 1 to 6 carbon atoms, C1-7 aliphatic or aromatic acyl group or C1-7 alkylsulphonyl or arylsulphonyl group and a salt thereof, to pharmaceutical compositions containing them, to the use as well as to process for preparing the novel compounds.The compounds of the general formula (1) are selective a2-adrenergic receptor-blocking substances and thus, they may be used for the treatment of depressive illnesses. |
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VIZI SZILVESZTER DR.,HU ; SOMOGYI GYORGY ,HU ; KOVACS GABOR ,HU ; HARSING LASZLO ,HU ; MARTON JENO DR.,HU ; SZANTAI CSABA ,HU</creatorcontrib><description>The invention relates to novel racemic or optically active berban derivatives of the general formula (I), whereinR' and R2 represent independently from the other a hydroxyl, straight or branched chain alkoxy group having 1 to 6 carbon atoms or R' and R7 together represent a C1-3 alkylenedioxy group;R3 and R4 represent independently from the other hydrogen, straight or branched chain alkyl group, having 1 to 4 carbon atoms and optionally substituted by hydroxyl group, or a C2-6 alkoxycarbonyl or cyano group; andR5 represents hydrogen, straight or branched chain alkyl group having 1 to 6 carbon atoms, C1-7 aliphatic or aromatic acyl group or C1-7 alkylsulphonyl or arylsulphonyl group and a salt thereof, to pharmaceutical compositions containing them, to the use as well as to process for preparing the novel compounds.The compounds of the general formula (1) are selective a2-adrenergic receptor-blocking substances and thus, they may be used for the treatment of depressive illnesses.</description><edition>5</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1990</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19900112&DB=EPODOC&CC=CS&NR=266586B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19900112&DB=EPODOC&CC=CS&NR=266586B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GAAL JOZSEF DR.,HU</creatorcontrib><creatorcontrib>TOTH ISTVAN ,HU</creatorcontrib><creatorcontrib>SZABO LAJOS ,HU</creatorcontrib><creatorcontrib>VIZI SZILVESZTER DR.,HU</creatorcontrib><creatorcontrib>SOMOGYI GYORGY ,HU</creatorcontrib><creatorcontrib>KOVACS GABOR ,HU</creatorcontrib><creatorcontrib>HARSING LASZLO ,HU</creatorcontrib><creatorcontrib>MARTON JENO DR.,HU</creatorcontrib><creatorcontrib>SZANTAI CSABA ,HU</creatorcontrib><title>METHOD OF NEW RACEMIC OR OPTICALLY ACTIVE BERBANE DERIVATIVES PRODUCTION</title><description>The invention relates to novel racemic or optically active berban derivatives of the general formula (I), whereinR' and R2 represent independently from the other a hydroxyl, straight or branched chain alkoxy group having 1 to 6 carbon atoms or R' and R7 together represent a C1-3 alkylenedioxy group;R3 and R4 represent independently from the other hydrogen, straight or branched chain alkyl group, having 1 to 4 carbon atoms and optionally substituted by hydroxyl group, or a C2-6 alkoxycarbonyl or cyano group; 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TOTH ISTVAN ,HU ; SZABO LAJOS ,HU ; VIZI SZILVESZTER DR.,HU ; SOMOGYI GYORGY ,HU ; KOVACS GABOR ,HU ; HARSING LASZLO ,HU ; MARTON JENO DR.,HU ; SZANTAI CSABA ,HU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CS266586B23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1990</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GAAL JOZSEF DR.,HU</creatorcontrib><creatorcontrib>TOTH ISTVAN ,HU</creatorcontrib><creatorcontrib>SZABO LAJOS ,HU</creatorcontrib><creatorcontrib>VIZI SZILVESZTER DR.,HU</creatorcontrib><creatorcontrib>SOMOGYI GYORGY ,HU</creatorcontrib><creatorcontrib>KOVACS GABOR ,HU</creatorcontrib><creatorcontrib>HARSING LASZLO ,HU</creatorcontrib><creatorcontrib>MARTON JENO DR.,HU</creatorcontrib><creatorcontrib>SZANTAI CSABA ,HU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GAAL JOZSEF DR.,HU</au><au>TOTH ISTVAN ,HU</au><au>SZABO LAJOS ,HU</au><au>VIZI SZILVESZTER DR.,HU</au><au>SOMOGYI GYORGY ,HU</au><au>KOVACS GABOR ,HU</au><au>HARSING LASZLO ,HU</au><au>MARTON JENO DR.,HU</au><au>SZANTAI CSABA ,HU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD OF NEW RACEMIC OR OPTICALLY ACTIVE BERBANE DERIVATIVES PRODUCTION</title><date>1990-01-12</date><risdate>1990</risdate><abstract>The invention relates to novel racemic or optically active berban derivatives of the general formula (I), whereinR' and R2 represent independently from the other a hydroxyl, straight or branched chain alkoxy group having 1 to 6 carbon atoms or R' and R7 together represent a C1-3 alkylenedioxy group;R3 and R4 represent independently from the other hydrogen, straight or branched chain alkyl group, having 1 to 4 carbon atoms and optionally substituted by hydroxyl group, or a C2-6 alkoxycarbonyl or cyano group; andR5 represents hydrogen, straight or branched chain alkyl group having 1 to 6 carbon atoms, C1-7 aliphatic or aromatic acyl group or C1-7 alkylsulphonyl or arylsulphonyl group and a salt thereof, to pharmaceutical compositions containing them, to the use as well as to process for preparing the novel compounds.The compounds of the general formula (1) are selective a2-adrenergic receptor-blocking substances and thus, they may be used for the treatment of depressive illnesses.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | METHOD OF NEW RACEMIC OR OPTICALLY ACTIVE BERBANE DERIVATIVES PRODUCTION |
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