METHOD OF MAKING THE 3/TETRAZOLO/1,5-B/PYRIDAZINYL-THIOME THYL/-DERIVATIVE OXY-IMINO-SUBSTITUTED CEFALOSPORINE
Heterocyclyl derivatives of oxy-imino-substituted cephalosporins are disclosed, such, for instance the compound 3-[(8-amino-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4 -thiazolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid and its pharmaceutically and veterinarily acceptable...
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| creator | CASABUONA,FERRUCCIO,IT NANNINI,GIULIANO,IT PERRONE,ETTORE,IT GRASSO,SILVIO,IT |
| description | Heterocyclyl derivatives of oxy-imino-substituted cephalosporins are disclosed, such, for instance the compound 3-[(8-amino-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4 -thiazolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid and its pharmaceutically and veterinarily acceptable salts. The compounds of the application have high antibacterial activity against Gram-positive and Gram-negative bacteria, including strong beta-lactamase producer Gram-negative microorganisms. |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | METHOD OF MAKING THE 3/TETRAZOLO/1,5-B/PYRIDAZINYL-THIOME THYL/-DERIVATIVE OXY-IMINO-SUBSTITUTED CEFALOSPORINE |
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