CRYSTALINE FORMS OF AN O-GLYCOPROTEIN-2-ACETAMIDO-2-DEOXY-3-D-GLUCOPYRANOSIDASE INHIBITOR
Described herein are solid forms of N-(4-fluoro-5-(((2S,4R)-4-((6-methoxypyrimidin-4-yl)oxy)-2-methylpyrrolidin-l-yl)methyl)thiazol-2-yl)acetamide, compound (I): (I) and the process of making said solid forms of compound (I). The present invention further relates to a pharmaceutical composition comp...
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| creator | LI, Chaomin WELDEAB, Asmerom CORREIA, Tae Kim LIN, Yiqing JENKINS, Aireal Diane |
| description | Described herein are solid forms of N-(4-fluoro-5-(((2S,4R)-4-((6-methoxypyrimidin-4-yl)oxy)-2-methylpyrrolidin-l-yl)methyl)thiazol-2-yl)acetamide, compound (I): (I) and the process of making said solid forms of compound (I). The present invention further relates to a pharmaceutical composition comprising crystalline Form A and Form B of compound (I), and methods of using said form and pharmaceutical composition in the treatment and prevention of Alzheimer's disease and related neurological disorders.
En la presente se describen formas sólidas de N-(4-fluoro-5-(((2S,4R)-4-((6-metoxipirimidin- 4-il)oxi)-2-metilpirrolidin-1-il)metil)tiazol-2-il)acetamida, compuesto (I): y el proceso de elaboración de dichas formas sólidas del compuesto (I). La presente invención además se refiere a una composición farmacéutica que comprende la Forma A y la Forma B cristalinas del compuesto (I), y métodos para usar dicha forma y composición farmacéutica en el tratamiento y prevención de la enfermedad de Alzheimer y trastornos neurológicos relacionados. |
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En la presente se describen formas sólidas de N-(4-fluoro-5-(((2S,4R)-4-((6-metoxipirimidin- 4-il)oxi)-2-metilpirrolidin-1-il)metil)tiazol-2-il)acetamida, compuesto (I): y el proceso de elaboración de dichas formas sólidas del compuesto (I). La presente invención además se refiere a una composición farmacéutica que comprende la Forma A y la Forma B cristalinas del compuesto (I), y métodos para usar dicha forma y composición farmacéutica en el tratamiento y prevención de la enfermedad de Alzheimer y trastornos neurológicos relacionados.</description><language>eng ; spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230602&DB=EPODOC&CC=CR&NR=20230118A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230602&DB=EPODOC&CC=CR&NR=20230118A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LI, Chaomin</creatorcontrib><creatorcontrib>WELDEAB, Asmerom</creatorcontrib><creatorcontrib>CORREIA, Tae Kim</creatorcontrib><creatorcontrib>LIN, Yiqing</creatorcontrib><creatorcontrib>JENKINS, Aireal Diane</creatorcontrib><title>CRYSTALINE FORMS OF AN O-GLYCOPROTEIN-2-ACETAMIDO-2-DEOXY-3-D-GLUCOPYRANOSIDASE INHIBITOR</title><description>Described herein are solid forms of N-(4-fluoro-5-(((2S,4R)-4-((6-methoxypyrimidin-4-yl)oxy)-2-methylpyrrolidin-l-yl)methyl)thiazol-2-yl)acetamide, compound (I): (I) and the process of making said solid forms of compound (I). The present invention further relates to a pharmaceutical composition comprising crystalline Form A and Form B of compound (I), and methods of using said form and pharmaceutical composition in the treatment and prevention of Alzheimer's disease and related neurological disorders.
En la presente se describen formas sólidas de N-(4-fluoro-5-(((2S,4R)-4-((6-metoxipirimidin- 4-il)oxi)-2-metilpirrolidin-1-il)metil)tiazol-2-il)acetamida, compuesto (I): y el proceso de elaboración de dichas formas sólidas del compuesto (I). La presente invención además se refiere a una composición farmacéutica que comprende la Forma A y la Forma B cristalinas del compuesto (I), y métodos para usar dicha forma y composición farmacéutica en el tratamiento y prevención de la enfermedad de Alzheimer y trastornos neurológicos relacionados.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyjEKwjAUgOEsDqLeIRcItOni-kxe7IM2T5IIZipF4iRaqPfHDB7A6f-HbyuyCTkmGMijdBzGKNlJ8JLVeciGL4ETkldagcEEI1mub5FvWXXKVnStKAfwHMlCREm-pxMlDnuxeczPtRx-3QnpMJleleU9lXWZ7-VVPpMJutFd07ZH6P4gX7n3MQY</recordid><startdate>20230602</startdate><enddate>20230602</enddate><creator>LI, Chaomin</creator><creator>WELDEAB, Asmerom</creator><creator>CORREIA, Tae Kim</creator><creator>LIN, Yiqing</creator><creator>JENKINS, Aireal Diane</creator><scope>EVB</scope></search><sort><creationdate>20230602</creationdate><title>CRYSTALINE FORMS OF AN O-GLYCOPROTEIN-2-ACETAMIDO-2-DEOXY-3-D-GLUCOPYRANOSIDASE INHIBITOR</title><author>LI, Chaomin ; WELDEAB, Asmerom ; CORREIA, Tae Kim ; LIN, Yiqing ; JENKINS, Aireal Diane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CR20230118A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LI, Chaomin</creatorcontrib><creatorcontrib>WELDEAB, Asmerom</creatorcontrib><creatorcontrib>CORREIA, Tae Kim</creatorcontrib><creatorcontrib>LIN, Yiqing</creatorcontrib><creatorcontrib>JENKINS, Aireal Diane</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LI, Chaomin</au><au>WELDEAB, Asmerom</au><au>CORREIA, Tae Kim</au><au>LIN, Yiqing</au><au>JENKINS, Aireal Diane</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CRYSTALINE FORMS OF AN O-GLYCOPROTEIN-2-ACETAMIDO-2-DEOXY-3-D-GLUCOPYRANOSIDASE INHIBITOR</title><date>2023-06-02</date><risdate>2023</risdate><abstract>Described herein are solid forms of N-(4-fluoro-5-(((2S,4R)-4-((6-methoxypyrimidin-4-yl)oxy)-2-methylpyrrolidin-l-yl)methyl)thiazol-2-yl)acetamide, compound (I): (I) and the process of making said solid forms of compound (I). The present invention further relates to a pharmaceutical composition comprising crystalline Form A and Form B of compound (I), and methods of using said form and pharmaceutical composition in the treatment and prevention of Alzheimer's disease and related neurological disorders.
En la presente se describen formas sólidas de N-(4-fluoro-5-(((2S,4R)-4-((6-metoxipirimidin- 4-il)oxi)-2-metilpirrolidin-1-il)metil)tiazol-2-il)acetamida, compuesto (I): y el proceso de elaboración de dichas formas sólidas del compuesto (I). La presente invención además se refiere a una composición farmacéutica que comprende la Forma A y la Forma B cristalinas del compuesto (I), y métodos para usar dicha forma y composición farmacéutica en el tratamiento y prevención de la enfermedad de Alzheimer y trastornos neurológicos relacionados.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | CRYSTALINE FORMS OF AN O-GLYCOPROTEIN-2-ACETAMIDO-2-DEOXY-3-D-GLUCOPYRANOSIDASE INHIBITOR |
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