CRYSTALINE FORMS OF AN O-GLYCOPROTEIN-2-ACETAMIDO-2-DEOXY-3-D-GLUCOPYRANOSIDASE INHIBITOR

Described herein are solid forms of N-(4-fluoro-5-(((2S,4R)-4-((6-methoxypyrimidin-4-yl)oxy)-2-methylpyrrolidin-l-yl)methyl)thiazol-2-yl)acetamide, compound (I): (I) and the process of making said solid forms of compound (I). The present invention further relates to a pharmaceutical composition comp...

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Bibliographische Detailangaben
Hauptverfasser:	LI, Chaomin, WELDEAB, Asmerom, CORREIA, Tae Kim, LIN, Yiqing, JENKINS, Aireal Diane
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Described herein are solid forms of N-(4-fluoro-5-(((2S,4R)-4-((6-methoxypyrimidin-4-yl)oxy)-2-methylpyrrolidin-l-yl)methyl)thiazol-2-yl)acetamide, compound (I): (I) and the process of making said solid forms of compound (I). The present invention further relates to a pharmaceutical composition comprising crystalline Form A and Form B of compound (I), and methods of using said form and pharmaceutical composition in the treatment and prevention of Alzheimer's disease and related neurological disorders. En la presente se describen formas sólidas de N-(4-fluoro-5-(((2S,4R)-4-((6-metoxipirimidin- 4-il)oxi)-2-metilpirrolidin-1-il)metil)tiazol-2-il)acetamida, compuesto (I): y el proceso de elaboración de dichas formas sólidas del compuesto (I). La presente invención además se refiere a una composición farmacéutica que comprende la Forma A y la Forma B cristalinas del compuesto (I), y métodos para usar dicha forma y composición farmacéutica en el tratamiento y prevención de la enfermedad de Alzheimer y trastornos neurológicos relacionados.