IMMUNOCONJUGATES
The present invention generally relates to mutant interleukin-7 polypeptides, immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-7 polypeptide and an antibody that binds to PD-1. In addition, the invention relates to polynucleotide molecules encoding the mutant interleuk...
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| creator | FREIMOSER-GRUNDSCHOBER, Anne CODARRI DEAK, Laura KLEIN, Christian UMAÑA, Pablo VARYPATAKI, Eleni Maria MOESSNER, Ekkehard LAUENER, Laura SCHULENBURG, Cindy |
| description | The present invention generally relates to mutant interleukin-7 polypeptides, immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-7 polypeptide and an antibody that binds to PD-1. In addition, the invention relates to polynucleotide molecules encoding the mutant interleukin-7 polypeptides or the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant interleukin-7 polypeptides, immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
La presente invención se refiere en general a polipéptidos de interleucina-7 mutante, inmunoconjugados, particularmente inmunoconjugados que comprenden un polipéptido de interleucina-7 mutante y un anticuerpo que se fija a PD-1. Además, la invención se refiere a moléculas de polinucleótidos que codifican los polipéptidos de interleucina-7 mutante o los inmunoconjugados, y vectores y células huésped que comprenden dichas moléculas de polinucleótidos. La invención se refiere además a métodos para producir los polipéptidos de interleucina-7 mutante, inmunoconjugados, composiciones farmacéuticas que los comprenden, y usos de estos. |
| format | Patent |
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La presente invención se refiere en general a polipéptidos de interleucina-7 mutante, inmunoconjugados, particularmente inmunoconjugados que comprenden un polipéptido de interleucina-7 mutante y un anticuerpo que se fija a PD-1. Además, la invención se refiere a moléculas de polinucleótidos que codifican los polipéptidos de interleucina-7 mutante o los inmunoconjugados, y vectores y células huésped que comprenden dichas moléculas de polinucleótidos. La invención se refiere además a métodos para producir los polipéptidos de interleucina-7 mutante, inmunoconjugados, composiciones farmacéuticas que los comprenden, y usos de estos.</description><language>eng ; spa</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221107&DB=EPODOC&CC=CR&NR=20220512A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25544,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221107&DB=EPODOC&CC=CR&NR=20220512A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FREIMOSER-GRUNDSCHOBER, Anne</creatorcontrib><creatorcontrib>CODARRI DEAK, Laura</creatorcontrib><creatorcontrib>KLEIN, Christian</creatorcontrib><creatorcontrib>UMAÑA, Pablo</creatorcontrib><creatorcontrib>VARYPATAKI, Eleni Maria</creatorcontrib><creatorcontrib>MOESSNER, Ekkehard</creatorcontrib><creatorcontrib>LAUENER, Laura</creatorcontrib><creatorcontrib>SCHULENBURG, Cindy</creatorcontrib><title>IMMUNOCONJUGATES</title><description>The present invention generally relates to mutant interleukin-7 polypeptides, immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-7 polypeptide and an antibody that binds to PD-1. In addition, the invention relates to polynucleotide molecules encoding the mutant interleukin-7 polypeptides or the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant interleukin-7 polypeptides, immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
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La presente invención se refiere en general a polipéptidos de interleucina-7 mutante, inmunoconjugados, particularmente inmunoconjugados que comprenden un polipéptido de interleucina-7 mutante y un anticuerpo que se fija a PD-1. Además, la invención se refiere a moléculas de polinucleótidos que codifican los polipéptidos de interleucina-7 mutante o los inmunoconjugados, y vectores y células huésped que comprenden dichas moléculas de polinucleótidos. La invención se refiere además a métodos para producir los polipéptidos de interleucina-7 mutante, inmunoconjugados, composiciones farmacéuticas que los comprenden, y usos de estos.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | IMMUNOCONJUGATES |
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