CONDENSED TRYCICLIC PYRROLES AS ALPHA-1 ANTITRYPSIN MODULATORS

The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I), tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated deriva...

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Hauptverfasser:	GAGNON, Kevin James, COTTRELL, Kevin Michael, LOOKER, Adam, BOYD, Michael John, ZAKY, Mariam, GARCIA BARRANTES, Pedro Manuel, FLEMING, Gabrielle Simone, RODAY, Setu, GIACOMETTI, Robert Daniel, FANNING, Lev Tyler Dewey, RONKIN, Steven M, JOHNSON, JR., Mac Arthur, STAVROPOULOS, Kathy, KESAVAN, Sarathy, THOMSON, Stephen, JONES, Peter, SAWANT, Rupa, GUIDO, Samantha, HOOD, Sarah Carol, SWETT, Rebecca Jane, NUHANT, Philippe Marcel, SHI, Yi, SHRESTHA, Muna, MAXWELL, Brad, BOUCHER, Diane, SPOSATO, Marisa, GREY JR., Ronald Lee, BRODNEY, Michael Aaron, MEDEK, Ales, BLIGH, Cavan McKeon, OVERHOFF, Kirk Alan, HURLEY, Dennis James, CLARK, Michael Philip, MAXWELL, John Patrick, DAMAGNEZ, Veronique, XU, Jinwang, FIMOGNARI, Robert Francis, LAI, Mei-Hsiu, BANDARAGE, Upul Keerthi, HALL, Amy Beth, TAPLEY, Timothy Lewis, ROEPER, Stefanie, LIU, Siying, GIROUX, Simon, TANG, Qing
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I), tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds. La descripción proporciona compuestos útiles para tratar la deficiencia de alfa-1 antitripsina (AATD), de acuerdo con la fórmula (I), tautómeros de estos, sales farmacéuticamente aceptables de los compuestos, sales farmacéuticamente aceptables de los tautómeros, derivados deuterados de los compuestos, derivados deuterados de los tautómeros y derivados deuterados de las sales, formas sólidas de esos compuestos y procesos para preparar esos compuestos