TRICÍCLICOS SUSTITUIDOS Y MÉTODOS PARA USARLOS
La presente invención se refiere a compuestos de fórmula (I), donde X, Y y R1 tienen cualquiera de los valores que se definen en la memoria descriptiva, y sales farmacéuticamente aceptables de éstos, que son útiles como agentes en el tratamiento de enfermedades y afecciones mediadas y moduladas por...
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| creator | ESMIEU, William Ramesh KYM, Philip R SEARLE, Xenia B LIU, Bo SCANIO, Marc J MALAGU, Karine Fabienne GRESZLER, Stephen N KOENIG, John R PATEL, Sachin V COWART, Marlon D WANG, Xueqing YEUNG, Ming C GFESSER, Gregory A VOIGHT, Eric BOGDAN, Andrew ALTENBACH, Robert J |
| description | La presente invención se refiere a compuestos de fórmula (I), donde X, Y y R1 tienen cualquiera de los valores que se definen en la memoria descriptiva, y sales farmacéuticamente aceptables de éstos, que son útiles como agentes en el tratamiento de enfermedades y afecciones mediadas y moduladas por el CFTR, tales como la fibrosis quística, el síndrome de Sjögren, la insuficiencia pancreática, la enfermedad pulmonar obstructiva crónica y la enfermedad obstructiva crónica de las vías respiratorias. También se dan a conocer composiciones farmacéuticas que comprenden uno o más compuestos de fórmula (I)
wherein X, Y, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I). |
| format | Patent |
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wherein X, Y, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180823&DB=EPODOC&CC=CR&NR=20180086A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180823&DB=EPODOC&CC=CR&NR=20180086A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ESMIEU, William Ramesh</creatorcontrib><creatorcontrib>KYM, Philip R</creatorcontrib><creatorcontrib>SEARLE, Xenia B</creatorcontrib><creatorcontrib>LIU, Bo</creatorcontrib><creatorcontrib>SCANIO, Marc J</creatorcontrib><creatorcontrib>MALAGU, Karine Fabienne</creatorcontrib><creatorcontrib>GRESZLER, Stephen N</creatorcontrib><creatorcontrib>KOENIG, John R</creatorcontrib><creatorcontrib>PATEL, Sachin V</creatorcontrib><creatorcontrib>COWART, Marlon D</creatorcontrib><creatorcontrib>WANG, Xueqing</creatorcontrib><creatorcontrib>YEUNG, Ming C</creatorcontrib><creatorcontrib>GFESSER, Gregory A</creatorcontrib><creatorcontrib>VOIGHT, Eric</creatorcontrib><creatorcontrib>BOGDAN, Andrew</creatorcontrib><creatorcontrib>ALTENBACH, Robert J</creatorcontrib><title>TRICÍCLICOS SUSTITUIDOS Y MÉTODOS PARA USARLOS</title><description>La presente invención se refiere a compuestos de fórmula (I), donde X, Y y R1 tienen cualquiera de los valores que se definen en la memoria descriptiva, y sales farmacéuticamente aceptables de éstos, que son útiles como agentes en el tratamiento de enfermedades y afecciones mediadas y moduladas por el CFTR, tales como la fibrosis quística, el síndrome de Sjögren, la insuficiencia pancreática, la enfermedad pulmonar obstructiva crónica y la enfermedad obstructiva crónica de las vías respiratorias. También se dan a conocer composiciones farmacéuticas que comprenden uno o más compuestos de fórmula (I)
wherein X, Y, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAICfJ0Ptzr7OPp7B-sEBwaHOIZEurpAmRHKvge7gzxBzEDHIMcFUKDHYN8_IN5GFjTEnOKU3mhNDeDgptriLOHbmpBfnxqcUFicmpeakm8c5CRgaGFgYGFmaMxEUoAw-Mnxg</recordid><startdate>20180823</startdate><enddate>20180823</enddate><creator>ESMIEU, William Ramesh</creator><creator>KYM, Philip R</creator><creator>SEARLE, Xenia B</creator><creator>LIU, Bo</creator><creator>SCANIO, Marc J</creator><creator>MALAGU, Karine Fabienne</creator><creator>GRESZLER, Stephen N</creator><creator>KOENIG, John R</creator><creator>PATEL, Sachin V</creator><creator>COWART, Marlon D</creator><creator>WANG, Xueqing</creator><creator>YEUNG, Ming C</creator><creator>GFESSER, Gregory A</creator><creator>VOIGHT, Eric</creator><creator>BOGDAN, Andrew</creator><creator>ALTENBACH, Robert J</creator><scope>EVB</scope></search><sort><creationdate>20180823</creationdate><title>TRICÍCLICOS SUSTITUIDOS Y MÉTODOS PARA USARLOS</title><author>ESMIEU, William Ramesh ; KYM, Philip R ; SEARLE, Xenia B ; LIU, Bo ; SCANIO, Marc J ; MALAGU, Karine Fabienne ; GRESZLER, Stephen N ; KOENIG, John R ; PATEL, Sachin V ; COWART, Marlon D ; WANG, Xueqing ; YEUNG, Ming C ; GFESSER, Gregory A ; VOIGHT, Eric ; BOGDAN, Andrew ; ALTENBACH, Robert J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CR20180086A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2018</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>ESMIEU, William Ramesh</creatorcontrib><creatorcontrib>KYM, Philip R</creatorcontrib><creatorcontrib>SEARLE, Xenia B</creatorcontrib><creatorcontrib>LIU, Bo</creatorcontrib><creatorcontrib>SCANIO, Marc J</creatorcontrib><creatorcontrib>MALAGU, Karine Fabienne</creatorcontrib><creatorcontrib>GRESZLER, Stephen N</creatorcontrib><creatorcontrib>KOENIG, John R</creatorcontrib><creatorcontrib>PATEL, Sachin V</creatorcontrib><creatorcontrib>COWART, Marlon D</creatorcontrib><creatorcontrib>WANG, Xueqing</creatorcontrib><creatorcontrib>YEUNG, Ming C</creatorcontrib><creatorcontrib>GFESSER, Gregory A</creatorcontrib><creatorcontrib>VOIGHT, Eric</creatorcontrib><creatorcontrib>BOGDAN, Andrew</creatorcontrib><creatorcontrib>ALTENBACH, Robert J</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ESMIEU, William Ramesh</au><au>KYM, Philip R</au><au>SEARLE, Xenia B</au><au>LIU, Bo</au><au>SCANIO, Marc J</au><au>MALAGU, Karine Fabienne</au><au>GRESZLER, Stephen N</au><au>KOENIG, John R</au><au>PATEL, Sachin V</au><au>COWART, Marlon D</au><au>WANG, Xueqing</au><au>YEUNG, Ming C</au><au>GFESSER, Gregory A</au><au>VOIGHT, Eric</au><au>BOGDAN, Andrew</au><au>ALTENBACH, Robert J</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>TRICÍCLICOS SUSTITUIDOS Y MÉTODOS PARA USARLOS</title><date>2018-08-23</date><risdate>2018</risdate><abstract>La presente invención se refiere a compuestos de fórmula (I), donde X, Y y R1 tienen cualquiera de los valores que se definen en la memoria descriptiva, y sales farmacéuticamente aceptables de éstos, que son útiles como agentes en el tratamiento de enfermedades y afecciones mediadas y moduladas por el CFTR, tales como la fibrosis quística, el síndrome de Sjögren, la insuficiencia pancreática, la enfermedad pulmonar obstructiva crónica y la enfermedad obstructiva crónica de las vías respiratorias. También se dan a conocer composiciones farmacéuticas que comprenden uno o más compuestos de fórmula (I)
wherein X, Y, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | TRICÍCLICOS SUSTITUIDOS Y MÉTODOS PARA USARLOS |
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