7-AZABICICLOS SUSTITUIDOS Y SU USO COMO MODULADORES DEL RECEPTOR DE OREXINA

La presente invención se refiere a compuestos de Fórmula I; en donde el anillo A es fenilo, naftalenilo, piridilo, quinolinilo, isoquinolinilo, imidazopiridilo, furanilo, tiazolilo, isoxazolilo, pirazolilo, imidazotiazolilo, bencimidazolilo, o indazolilo; R1 es H, alquilo, alcoxi hidroxialquileno, OH, halo, fenilo, triazolilo, oxazolilo, isoxazolilo, piridilo, pirimidinilo, pirazinilo, piridazinilo, piperazinilo, pirazolilo, oxadiazolilo, pirrolidinilo, tiofenilo, morfolinilo, o dialquilamino; R2 es H, alquilo, alcoxi hidroxialquileno, o halo; Z es NH, N-alquilo, u O; R5 es piridilo, pirimidinilo, pirazinilo, piridazinilo, quinazolinilo, quinoxalinilo, pirazolilo, benzoxazolilo, imidazopirazinilo, triazolopirazinilo. wherein A is phenyl, naphthalenyl, pyridyl, quinolinyl, isoquinolinyl, imidazopyridyl, furanyl, thiazolyl, isoxazolyl, pyrazolyl, imidazothiazolyl, benzimidazolyl, or indazolyl; R1 is H, alkyl, alkoxy, hydroxyalkylene, OH, halo, phenyl, triazolyl, oxazolyl, isoxazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, piperazinyl, pyrazolyl, oxadiazolyl, pyrrolidinyl, thiophenyl, morpholinyl, or dialkylamino; R2 is H, alkyl, alkoxy, hydroxyalkylene, or halo; Z is NH, N-alkyl, or O; R5 is pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, quinazolinyl, quinoxalinyl, pyrazolyl, benzoxazolyl, imidazopyrazinyl, or triazolopyrazinyl, optionally substituted with a one or two substituents independently selected from the group consisting of alkyl, alkoxy, or halo; and n is 0 or 1. Methods of making the compounds of Formula I are also described. The invention also relates to pharmaceutical compositions comprising compounds of Formula I. Methods of using the compounds of the invention are also within the scope of the invention.