DERIVADOS PIRIDIN-2-IL-AMINO-1,2,4-TIADIAZOL COMO ACTIVADORES GLUCOQUINASA PARA EL TRATAMIENTO DE LA DIABETES MELLITUS
Se proporcionan compuestos de la Fórmula I, en donde R2, R3, R13, L y D2 son lo definido en la memoria descriptiva, que son útiles en el tratamiento y/o en la prevención de enfermedades o trastornos mediados por niveles deficientes de actividad de glucocinasa o que se pueden tratar activando glucoci...
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| creator | HINKLIN, RONALD JAY GUNAWARDANA, INDRANI W SINGH, AJAY CONDROSKI, KEVIN RONALD TURNER, TIMOTHY M AICHER, THOMAS DANIEL FELL, JAY BRADFORD WALLACE, ELI M CHICARELLI, MARK JOSEPH BOYD, STEVEN ARMEN FISCHER, JOHN P |
| description | Se proporcionan compuestos de la Fórmula I, en donde R2, R3, R13, L y D2 son lo definido en la memoria descriptiva, que son útiles en el tratamiento y/o en la prevención de enfermedades o trastornos mediados por niveles deficientes de actividad de glucocinasa o que se pueden tratar activando glucocinasa que incluyen, en forma no taxativa, diabetes mellitus, deterioro de tolerancia de la glucosa, IFG (deterioro de glucosa en ayunas) e IFG (deterioro de glucemia en ayunas), así como otras enfermedades y trastornos tales como aquellos discutidos en la presente.
Provided are compounds of Formula I
wherein R 2 , R 3 , R 13 , L and D 2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein. |
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Provided are compounds of Formula I
wherein R 2 , R 3 , R 13 , L and D 2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150430&DB=EPODOC&CC=CR&NR=20150131A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150430&DB=EPODOC&CC=CR&NR=20150131A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HINKLIN, RONALD JAY</creatorcontrib><creatorcontrib>GUNAWARDANA, INDRANI W</creatorcontrib><creatorcontrib>SINGH, AJAY</creatorcontrib><creatorcontrib>CONDROSKI, KEVIN RONALD</creatorcontrib><creatorcontrib>TURNER, TIMOTHY M</creatorcontrib><creatorcontrib>AICHER, THOMAS DANIEL</creatorcontrib><creatorcontrib>FELL, JAY BRADFORD</creatorcontrib><creatorcontrib>WALLACE, ELI M</creatorcontrib><creatorcontrib>CHICARELLI, MARK JOSEPH</creatorcontrib><creatorcontrib>BOYD, STEVEN ARMEN</creatorcontrib><creatorcontrib>FISCHER, JOHN P</creatorcontrib><title>DERIVADOS PIRIDIN-2-IL-AMINO-1,2,4-TIADIAZOL COMO ACTIVADORES GLUCOQUINASA PARA EL TRATAMIENTO DE LA DIABETES MELLITUS</title><description>Se proporcionan compuestos de la Fórmula I, en donde R2, R3, R13, L y D2 son lo definido en la memoria descriptiva, que son útiles en el tratamiento y/o en la prevención de enfermedades o trastornos mediados por niveles deficientes de actividad de glucocinasa o que se pueden tratar activando glucocinasa que incluyen, en forma no taxativa, diabetes mellitus, deterioro de tolerancia de la glucosa, IFG (deterioro de glucosa en ayunas) e IFG (deterioro de glucemia en ayunas), así como otras enfermedades y trastornos tales como aquellos discutidos en la presente.
Provided are compounds of Formula I
wherein R 2 , R 3 , R 13 , L and D 2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNy0EKwjAQQNFuXIh6hzlAA02rBxiTUQfSRpOpCzelSFyJFiqe3yIewNXf_DfP3pYCn9H6CEcObLlRpWKnsObGK52X-VoJo2W8eAfG1x7QyFcEirB3rfGnlhuMCEcMCORAAsrkqREPlsAhTHxLMv01OcfSxmU2u_X3Ma1-XWSwIzEHlYZnl8ahv6ZHenUmlIXeFLrSWP2xfABJ4ThL</recordid><startdate>20150430</startdate><enddate>20150430</enddate><creator>HINKLIN, RONALD JAY</creator><creator>GUNAWARDANA, INDRANI W</creator><creator>SINGH, AJAY</creator><creator>CONDROSKI, KEVIN RONALD</creator><creator>TURNER, TIMOTHY M</creator><creator>AICHER, THOMAS DANIEL</creator><creator>FELL, JAY BRADFORD</creator><creator>WALLACE, ELI M</creator><creator>CHICARELLI, MARK JOSEPH</creator><creator>BOYD, STEVEN ARMEN</creator><creator>FISCHER, JOHN P</creator><scope>EVB</scope></search><sort><creationdate>20150430</creationdate><title>DERIVADOS PIRIDIN-2-IL-AMINO-1,2,4-TIADIAZOL COMO ACTIVADORES GLUCOQUINASA PARA EL TRATAMIENTO DE LA DIABETES MELLITUS</title><author>HINKLIN, RONALD JAY ; GUNAWARDANA, INDRANI W ; SINGH, AJAY ; CONDROSKI, KEVIN RONALD ; TURNER, TIMOTHY M ; AICHER, THOMAS DANIEL ; FELL, JAY BRADFORD ; WALLACE, ELI M ; CHICARELLI, MARK JOSEPH ; BOYD, STEVEN ARMEN ; FISCHER, JOHN P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CR20150131A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HINKLIN, RONALD JAY</creatorcontrib><creatorcontrib>GUNAWARDANA, INDRANI W</creatorcontrib><creatorcontrib>SINGH, AJAY</creatorcontrib><creatorcontrib>CONDROSKI, KEVIN RONALD</creatorcontrib><creatorcontrib>TURNER, TIMOTHY M</creatorcontrib><creatorcontrib>AICHER, THOMAS DANIEL</creatorcontrib><creatorcontrib>FELL, JAY BRADFORD</creatorcontrib><creatorcontrib>WALLACE, ELI M</creatorcontrib><creatorcontrib>CHICARELLI, MARK JOSEPH</creatorcontrib><creatorcontrib>BOYD, STEVEN ARMEN</creatorcontrib><creatorcontrib>FISCHER, JOHN P</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HINKLIN, RONALD JAY</au><au>GUNAWARDANA, INDRANI W</au><au>SINGH, AJAY</au><au>CONDROSKI, KEVIN RONALD</au><au>TURNER, TIMOTHY M</au><au>AICHER, THOMAS DANIEL</au><au>FELL, JAY BRADFORD</au><au>WALLACE, ELI M</au><au>CHICARELLI, MARK JOSEPH</au><au>BOYD, STEVEN ARMEN</au><au>FISCHER, JOHN P</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>DERIVADOS PIRIDIN-2-IL-AMINO-1,2,4-TIADIAZOL COMO ACTIVADORES GLUCOQUINASA PARA EL TRATAMIENTO DE LA DIABETES MELLITUS</title><date>2015-04-30</date><risdate>2015</risdate><abstract>Se proporcionan compuestos de la Fórmula I, en donde R2, R3, R13, L y D2 son lo definido en la memoria descriptiva, que son útiles en el tratamiento y/o en la prevención de enfermedades o trastornos mediados por niveles deficientes de actividad de glucocinasa o que se pueden tratar activando glucocinasa que incluyen, en forma no taxativa, diabetes mellitus, deterioro de tolerancia de la glucosa, IFG (deterioro de glucosa en ayunas) e IFG (deterioro de glucemia en ayunas), así como otras enfermedades y trastornos tales como aquellos discutidos en la presente.
Provided are compounds of Formula I
wherein R 2 , R 3 , R 13 , L and D 2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | DERIVADOS PIRIDIN-2-IL-AMINO-1,2,4-TIADIAZOL COMO ACTIVADORES GLUCOQUINASA PARA EL TRATAMIENTO DE LA DIABETES MELLITUS |
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