QUINAZOLINES FOR PDK1 INHIBITION

The invention provides novel compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.

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Bibliographische Detailangaben
Hauptverfasser:	RAMURTHY, SAVITHRI, MURRAY JEREMY M, WANG, XIAOJING M, ZHOU, YASHEEN, LIN, XIAODONG, SUBRAMANIAN, SHARADA, BASHAM, STEVEN E, DOVE, JEFFREY, AIKAWA, MINA, AMIRI, PAYMAN, JAIN, RAMA, SHU, WEI, RICO, ALICE C, WARNE, ROBERT L
Format:	Patent
Sprache:	spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides novel compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.