PURIFICATION OF 5-PYRIMIDINECARBOXAMIDES

A process for the purification of 5-pyrimidinecarboxamides to highly purified states which are essentially insoluble in both organic and inorganic solvents comprises contact with an organic base to form an adduct. The adduct is purified through recrystallization and the desired 5-pyrimidinecarboxamide is regenerated from the adduct in highly purified form with acid. Additionally, an adduct resulting from the combination of a 5-pyrimidinecarboxamide with an organic base is provided, which adduct is capable of being purified using recrystallization techniques, whereas the 5-pyrimidinecarboxamide is not itself capable of being so purified due to its relative insolubility in organic and inorganic solvents.