3,4-di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands
The present invention relates to a 3,4-substituted cyclobutene-1,2-diketone as a CXC-ligand for a receptor and there are disclosed compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chr...
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| creator | TAVERAS ARTHUR G.,AKI CYNTHIA J.,BOND RICHARD W.,CHAO JIANPING,DWYER MICHAEL,FERREIRA JOHAN A.,CHAOJIANHUA,YU YOUNONG,BALDWIN JOHN J.,KAISER BERND,LI GE,MERRITT ROBERT J.,NELSON KINGSLEY H.,ROKOSZ LA |
| description | The present invention relates to a 3,4-substituted cyclobutene-1,2-diketone as a CXC-ligand for a receptor and there are disclosed compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer. |
| format | Patent |
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| language | eng |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 3,4-di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands |
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